Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-016 ISMRM Abstract

Establishing a Healthy Reference Distribution for Standardized Mapping of 129Xe Red Blood Cell Chemical Shift Heterogeneity

Primary: Body - Lung
Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)
369-05-016 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J
Keywords: MRSI Hyperpolarized 129Xe MRI Reference values Hyperpolarized Xenon-129 MRI Pulmonary hypertension
Accepted
Anna Costelle 1, Suphachart Leewiwatwong2, Seth N Lee1, David Mummy1,3, John P Mugler4, Sudarshan Rajagopal5, Bastiaan Driehuys1,2,3
1Medical Physics Graduate Program, Duke University, Durham, United States of America
2Department of Biomedical Engineering, Duke University, Durham, United States of America
3Department of Radiology, Duke University, Durham, United States of America
4School of Medicine, University of Virginia, Charlottesville, United States of America
5Cardiology, Duke University Medical Center, Durham, United States of America
Presenting Author: Anna Costelle

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Norquay G, Leung G, Stewart NJ, Wolber J, Wild JM. (129) Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized (129) Xe NMR. Magn Reson Med. 2017;77:1399-1408. doi: 10.1002/mrm.26225 [doi]
2. Wolber J, Cherubini A, Leach MO, Bifone A. Hyperpolarized 129Xe NMR as a probe for blood oxygenation. Magn Reson Med. 2000;43:491-496. doi: 10.1002/(sici)1522-2594(200004)43:4<491::aid-mrm1>3.0.co;2-6 [doi]
3. Bier EA, Alenezi F, Lu J, Wang Z, Mammarappallil JG, O'Sullivan-Murphy B, Erkanli A, Driehuys B, Rajagopal S. Noninvasive diagnosis of pulmonary hypertension with hyperpolarised (129)Xe magnetic resonance imaging and spectroscopy. ERJ Open Res. 2022;8. doi: 10.1183/23120541.00035-2022 [doi]
4. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, et al. Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;186:261-272. doi: 10.1164/rccm.201201-0164OC [doi]
5. Kuikka JT. Effect of increasing blood flow on distribution of pulmonary transit times in man. Physiol Meas. 2000;21:241-250. doi: 10.1088/0967-3334/21/2/304 [doi]
6. Presson RG, Jr., Hanger CC, Godbey PS, Graham JA, Lloyd TC, Jr., Wagner WW, Jr. Effect of increasing flow on distribution of pulmonary capillary transit times. J Appl Physiol (1985). 1994;76:1701-1711. doi: 10.1152/jappl.1994.76.4.1701 [doi]
7. Costelle A, Leewiwatwong S, III JPM, Rajagopal S, Mummy D, Driehuys B. Mapping the Chemical Shift of 129Xe in Red Blood Cells as a Biomarker for Pulmonary Hypertension. In: ISMRM Annual Meeting. Honolulu, HI; 2025.
8. Leewiwatwong S, Bechtel A, Mummy D, Zhang S, Lu J, Costelle A, Cleveland ZI, Willmering M, Parra-Robles J, Fain S, et al. Establishing standardized healthy reference distributions and values for multisite (129)Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms. Magn Reson Med. 2025;94:1684-1699. doi: 10.1002/mrm.30586 [doi]
9. Niedbalski PJ, Hall CS, Castro M, Eddy RL, Rayment JH, Svenningsen S, Parraga G, Zanette B, Santyr GE, Thomen RP, et al. Protocols for multi-site trials using hyperpolarized (129) Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the (129) Xe MRI clinical trials consortium. Magn Reson Med. 2021;86:2966-2986. doi: 10.1002/mrm.28985 [doi]
10. Bier E. Dynamic 129Xe Magnetic Resonance Spectroscopy: Development and Application in Diverse Cardiopulmonary Diseases. In: Biomedical Engineering. Duke University; 2021.
11. Leewiwatwong S, Lu J, Dummer I, Yarnall K, Mummy D, Wang Z, Driehuys B. Combining neural networks and image synthesis to enable automatic thoracic cavity segmentation of hyperpolarized (129)Xe MRI without proton scans. Magn Reson Imaging. 2023;103:145-155. doi: 10.1016/j.mri.2023.07.001 [doi]
12. Westoo C, Norvik C, Peruzzi N, van der Have O, Lovric G, Jeremiasen I, Tran PK, Mokso R, de Jesus Perez V, Brunnstrom H, et al. Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT. Am J Physiol Lung Cell Mol Physiol. 2021;321:L17-L28. doi: 10.1152/ajplung.00432.2020 [doi]
13. Mummy D, Zhang S, Bechtel A, Lu J, Mammarappallil J, Leewiwatwong S, Costelle A, Swaminathan A, Driehuys B. Functional gas exchange measures on 129Xe MRI and spectroscopy are associated with age, sex, and BMI in healthy subjects. Frontiers in Medicine. 2024;11. doi: 10.3389/fmed.2024.1342499 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-05-016