Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
451-02-001 / 451-02-001 ISMRM Abstract

Mapping Molecular Brain Connectivity Using Glutamate-Weighted CEST MRI: Effects of Nicotine

Primary: Contrast Mechanisms - Novel Contrast Mechanisms
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
451-02-001 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
451-02-001 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: CEST MRI GluCEST Graph theory analysis Nicotine Molecular connectivity
Accepted
Joel Jarusek1,2, Mariano G Uberti2, Adarsha Bhattarai3, Chathumi Samaraweera3, Dongming Peng3, Aditya N Bade4, Yutong Liu 2,4
1Department of Physics, University of Nebraska Omaha, Omaha, United States of America
2Department of Radiology, University of Nebraska Medical Center, Omaha, United States of America
3Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, United States of America
4Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, United States of America
Presenting Author: Yutong Liu

Synopsis

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References

1. Lv H, Wang Z, Tong E, Williams LM, Zaharchuk G, Zeineh M, Goldstein-Piekarski AN, Ball TM, Liao C, Wintermark M. Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know. AJNR Am J Neuroradiol. 2018;39(8):1390-9. Epub 2018/01/20. doi: 10.3174/ajnr.A5527. PubMed PMID: 29348136; PMCID: PMC6051935. [doi] [pmid]
2. Soares JM, Magalhães R, Moreira PS, Sousa A, Ganz E, Sampaio A, Alves V, Marques P, Sousa N. A Hitchhiker's Guide to Functional Magnetic Resonance Imaging. Frontiers in Neuroscience. 2016;10. doi: 10.3389/fnins.2016.00515. [doi]
3. Calabrese E, Badea A, Cofer G, Qi Y, Johnson GA. A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data. Cereb Cortex. 2015;25(11):4628-37. Epub 2015/06/07. doi: 10.1093/cercor/bhv121. PubMed PMID: 26048951; PMCID: PMC4715247. [doi] [pmid]
4. Lazar M. Mapping brain anatomical connectivity using white matter tractography. NMR Biomed. 2010;23(7):821-35. Epub 2010/10/05. doi: 10.1002/nbm.1579. PubMed PMID: 20886567; PMCID: PMC4503207. [doi] [pmid]
5. Mangin JF, Fillard P, Cointepas Y, Le Bihan D, Frouin V, Poupon C. Toward global tractography. Neuroimage. 2013;80:290-6. doi: https://doi.org/10.1016/j.neuroimage.2013.04.009. [doi]
6. Reed MB, Cocchi L, Sander CY, Chen J, Matheson GJ, Fisher P, Volpi T, Khattar N, DeLorenzo C, Gryglewski G, Silberbauer LR, Murgaš M, Godbersen GM, Nics L, Walter M, Hacker M, Bertoldo A, Lubberink M, Silfstein M, Ogden RT, Mann JJ, Suhara T, Varrone A, Boellaard R, Gunn RN, Hammers A, Biswal B, Rosen B, Knudsen GM, Carson R, Price J, Lanzenberger R, Hahn A. Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography. Eur J Nucl Med Mol Imaging. 2025. Epub 20250602. doi: 10.1007/s00259-025-07357-1. PubMed PMID: 40455254. [doi] [pmid]
7. Hanania JU, Reimers E, Bevington CWJ, Sossi V. PET-based brain molecular connectivity in neurodegenerative disease. Curr Opin Neurol. 2024;37(4):353-60. Epub 20240530. doi: 10.1097/wco.0000000000001283. PubMed PMID: 38813843. [doi] [pmid]
8. Carli G, Tondo G, Boccalini C, Perani D. Brain Molecular Connectivity in Neurodegenerative Conditions. Brain Sci. 2021;11(4). Epub 20210328. doi: 10.3390/brainsci11040433. PubMed PMID: 33800680; PMCID: PMC8067093. [doi] [pmid]
9. Sala A, Perani D. Brain Molecular Connectivity in Neurodegenerative Diseases: Recent Advances and New Perspectives Using Positron Emission Tomography. Front Neurosci. 2019;13:617. Epub 20190614. doi: 10.3389/fnins.2019.00617. PubMed PMID: 31258466; PMCID: PMC6587303. [doi] [pmid]
10. Yakushev I, Drzezga A, Habeck C. Metabolic connectivity: methods and applications. Current Opinion in Neurology. 2017;30(6):677-85. doi: 10.1097/wco.0000000000000494. PubMed PMID: 00019052-201712000-00018. [doi] [pmid]
11. Volkow ND, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Alia-Klein N, Logan J, Wong C, Thanos PK, Ma Y, Pradhan K. Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity (Silver Spring). 2009;17(1):60-5. Epub 2008/10/25. doi: 10.1038/oby.2008.469. PubMed PMID: 18948965; PMCID: PMC2681079. [doi] [pmid]
12. Wang GJ, Volkow ND, Telang F, Jayne M, Ma Y, Pradhan K, Zhu W, Wong CT, Thanos PK, Geliebter A, Biegon A, Fowler JS. Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation. Proc Natl Acad Sci U S A. 2009;106(4):1249-54. Epub 2009/01/24. doi: 10.1073/pnas.0807423106. PubMed PMID: 19164587; PMCID: PMC2633545. [doi] [pmid]
13. Apostolova I, Block S, Buchert R, Osen B, Conradi M, Tabrizian S, Gensichen S, Schröder-Hartwig K, Fricke S, Rufer M, Weiss A, Hand I, Clausen M, Obrocki J. Effects of behavioral therapy or pharmacotherapy on brain glucose metabolism in subjects with obsessive–compulsive disorder as assessed by brain FDG PET. Psychiatry Research: Neuroimaging. 2010;184(2):105-16. doi: https://doi.org/10.1016/j.pscychresns.2010.08.012. [doi]
14. Hahn A, Gryglewski G, Nics L, Hienert M, Rischka L, Vraka C, Sigurdardottir H, Vanicek T, James GM, Seiger R, Kautzky A, Silberbauer L, Wadsak W, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R. Quantification of Task-Specific Glucose Metabolism with Constant Infusion of <sup>18</sup>F-FDG. Journal of Nuclear Medicine. 2016;57(12):1933-40. doi: 10.2967/jnumed.116.176156. [doi]
15. Lanzenberger R, Kranz GS, Haeusler D, Akimova E, Savli M, Hahn A, Mitterhauser M, Spindelegger C, Philippe C, Fink M, Wadsak W, Karanikas G, Kasper S. Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas. Neuroimage. 2012;63(2):874-81. doi: https://doi.org/10.1016/j.neuroimage.2012.07.023. [doi]
16. Amend M, Ionescu TM, Di X, Pichler BJ, Biswal BB, Wehrl HF. Functional resting-state brain connectivity is accompanied by dynamic correlations of application-dependent [(18)F]FDG PET-tracer fluctuations. Neuroimage. 2019;196:161-72. Epub 20190411. doi: 10.1016/j.neuroimage.2019.04.034. PubMed PMID: 30981858; PMCID: PMC10673660. [doi] [pmid]
17. Cervenka S, Varrone A, Fransén E, Halldin C, Farde L. PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans. Synapse. 2010;64(6):478-85. doi: https://doi.org/10.1002/syn.20765. [doi]
18. Tuominen L, Nummenmaa L, Keltikangas-Järvinen L, Raitakari O, Hietala J. Mapping neurotransmitter networks with PET: An example on serotonin and opioid systems. Human Brain Mapping. 2014;35(5):1875-84. doi: https://doi.org/10.1002/hbm.22298. [doi]
19. Pillai RL, Zhang M, Yang J, Mann JJ, Oquendo MA, Parsey RV, DeLorenzo C. Molecular connectivity disruptions in males with major depressive disorder. Journal of Cerebral Blood Flow & Metabolism. 2019;39(8):1623-34. doi: 10.1177/0271678x18764053. PubMed PMID: 29519187. [doi] [pmid]
20. Vinogradov E, Sherry AD, Lenkinski RE. CEST: from basic principles to applications, challenges and opportunities. Journal of magnetic resonance (San Diego, Calif : 1997). 2013;229:155-72. Epub 2013/01/01. doi: 10.1016/j.jmr.2012.11.024. PubMed PMID: 23273841; PMCID: PMC3602140. [doi] [pmid]
21. Ward KM, Aletras AH, Balaban RS. A New Class of Contrast Agents for MRI Based on Proton Chemical Exchange Dependent Saturation Transfer (CEST). Journal of Magnetic Resonance. 2000;143(1):79-87. doi: https://doi.org/10.1006/jmre.1999.1956. [doi]
22. Wu B, Warnock G, Zaiss M, Lin C, Chen M, Zhou Z, Mu L, Nanz D, Tuura R, Delso G. An overview of CEST MRI for non-MR physicists. EJNMMI physics. 2016;3(1):19. Epub 2016/08/27. doi: 10.1186/s40658-016-0155-2. PubMed PMID: 27562024; PMCID: PMC4999387. [doi] [pmid]
23. Liu Y, Uberti MG, Bhattarai A, Samaraweera C, Bade AN, Peng D. Mapping Glutamate Networks in the Mouse Brain Using CEST MRI. ISMRM Annual Meeting; Honolulu, HI2025.
24. Paech D, Radbruch A. Dynamic Glucose-Enhanced MR Imaging. Magn Reson Imaging Clin N Am. 2021;29(1):77-81. Epub 2020/11/26. doi: 10.1016/j.mric.2020.09.009. PubMed PMID: 33237017. [doi] [pmid]
25. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med. 2009;61(6):1441-50. Epub 2009/04/10. doi: 10.1002/mrm.21873. PubMed PMID: 19358232; PMCID: PMC2860191. [doi] [pmid]
26. Australian Mouse Brain Mapping Consortium [Internet].
27. Rubinov M, Sporns O. Complex network measures of brain connectivity: Uses and interpretations. Neuroimage. 2010;52(3):1059-69. doi: https://doi.org/10.1016/j.neuroimage.2009.10.003. [doi]

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http://echo.ismrm.org/p/ISMRM2026/451-02-001