551-03-014 / 551-03-014 ISMRM Abstract

Disease progression modelling of white matter microstructure in Alzheimer’s disease: temporal ordering and predictive utility

Primary: Diffusion - Microstructure

Secondary: Neuro - Alzheimer's Disease

551-03-014 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1

Keywords: Modelling Alzheimer's Disease White Matter Diffusion Tensor Imaging (DTI) Cognition decline

Accepted

Christopher S Parker ^1,2, Philip S Weston², Gary Zhang¹, Neil P Oxtoby¹

¹Hawkes Institute Department of Computer Science, UCL, London, United Kingdom

²Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, United Kingdom

Presenting Author: Christopher S Parker

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References

1. Andrei, S., Coley, N., Lovestone, S., Aisen, P., Vellas, B. Prevention of sporadic Alzheimer’s disease: lessons learned from clinical trials and future directions. Lancet Neurol. 14:926-44 (2015).

2. Jack Jr, C.R., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., Weiner, M.W., Petersen, R.C. and Trojanowski, J.Q.. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. The Lancet Neurology, 9(1), 119-128 (2010)

3. Wang Q, Wang, Y., Liu, J., Sutphen, C., Cruchaga, C., Blazey, T. et. al. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer disease. NeuroImage: Clinical. 22(1), 101767 (2019).

4. Sexton C.E., Kalu U.G., Filippini N., Mackay C.E., Ebmeier K.P.. A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. 32(12) (2011)

5. Douaud, G., Menke, R.A., Gass, A., Monsch, A.U., Rao, A., Whitcher, B., Zamboni, G., Matthews, P.M., Sollberger, M. and Smith, S., 2013. Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease. Journal of Neuroscience, 33(5) (2013)

6. Parker C.S., Oxtoby, N.P., Young, A.L., Alexander, D.C., Zhang, H., ADNI. Parsimonious EBM: generalising the event-based model of disease progression for simultaneous events. NeuroImage, 311, 121162 (2025)

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/551-03-014