Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-04-006 ISMRM Abstract

Treatment with NAMPT Activator Enhances Cerebral Glucose Metabolism in AD Mice

Primary: Neuro - Alzheimer's Disease
Secondary: Preclinical Animal & in vitro MR - Biomarkers
366-04-006 · Probes and Targets · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row G
Keywords: Alzheimer's Disease Deuterium Metabolic Imaging Glucose metabolism Nicotinamide phosphoribosyltransferase Neurometabolism
Accepted
Sunil K Khokhar1, Narayan Datt Soni1, Anshuman Swain1, Abeer Mathur1, Paul S Jacobs1, Dipak Roy1, Halvor Juul1, Blake A Benyard 1, Dushyant Kumar1, RAVI PRAKASH REDDY NANGA1, Ravinder Reddy1, Mohammad Haris1
1University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Blake A Benyard

Synopsis

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References

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2. 2. Butterfield DA, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 2019 Mar;20(3):148–60.
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7. 7. Imai S ichiro. Nicotinamide phosphoribosyltransferase (Nampt): A link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20–8.
8. 8. Frederick DW, Loro E, Liu L, Davila A, Chellappa K, Silverman IM, et al. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 Aug 9;24(2):269–82.
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11. 11. McDonald TS, Lerskiatiphanich T, Woodruff TM, McCombe PA, Lee JD. Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. J Cereb Blood Flow Metab. 2023 Jan;43(1):26–43.
12. 12. Xing S, Hu Y, Huang X, Shen D, Chen C. Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer’s disease mouse models. Mol Med Rep. 2019 Dec;20(6):5163–71.
13. 13. Zhu Y, Xu P, Huang X, Shuai W, Liu L, Zhang S, et al. From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases. Front Pharmacol. 2022 July 12;13:920113.
14. 14. Soni ND, Swain A, Jacobs P, Juul H, Armbruster R, Nanga RPR, et al. In vivo assessment of β-hydroxybutyrate metabolism in mouse brain using deuterium (2H) MRS. Magnetic resonance in medicine. 2023 July;90(1):259–69.
15. 15. Lu M, Zhu XH, Zhang Y, Mateescu G, Chen W. Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2017 Nov;37(11):3518–30.
16. 16. (ISMRM 2025) <strong>Investigating the Relation Between NAD+ Biosynthesis and Glucose Metabolism in a Mouse Model of Alzheimer’s Disease using <em>In Vivo</em> 2H MRS</strong> [Internet]. [cited 2025 Oct 28]. Available from: https://archive.ismrm.org/2025/4922_EMnlZWSL6.html
17. 17. Gardell SJ, Hopf M, Khan A, Dispagna M, Hampton Sessions E, Falter R, et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat Commun. 2019 July 19;10(1):3241.
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19. 19. Yin F. Lipid metabolism and Alzheimer’s disease: clinical evidence, mechanistic link and therapeutic promise. FEBS J. 2023 Mar;290(6):1420–53.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-04-006