430-04-005 ISMRM Abstract

In vivo evaluation of hepatic glutathione dynamics following pharmacological inhibition using 11.7 T ¹H MRS

Primary: Preclinical Animal & in vitro MR - Biomarkers

Secondary: Body - Liver

430-04-005 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60

Keywords: Liver MRS Ultra high field MRI Metabolomics

Accepted

NITTA NOBUHIRO ¹, Yuji Komaki¹, Suemizu Hiroshi¹, Yoneda Nao¹, Uehara Shotaro¹, Suematsu Makoto¹

¹Central Institute for Experimental Medicine and Life Science, Tokyo, Japan

Presenting Author: NITTA NOBUHIRO

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References

1. Behar KL, Ugurbil K, et al. Noninvasive in vivo magnetic resonance measures of glutathione synthesis and flux in human and rat liver as an oxidative stress biomarker. Hepatology. 2014;59(4):139–149. doi:10.1002/hep.26695 PMID: 24242936 [doi] [pmid]

2. Taylor TL, Hazlewood CF, et al. In vivo monitoring of hepatic glutathione in anesthetized rats by ¹³C NMR. Magn Reson Med. 2001;46(1):113–121. doi:10.1002/mrm.1181 PMID: 11443718 [doi] [pmid]

3. Platt T, et al. 7 Tesla and beyond: advanced methods and clinical applications of ultra-high-field MRI. Invest Radiol. 2021;56(11):659–678. PMID: 33844183 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/430-04-005