Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-06-014 ISMRM Abstract

Proton Density Fat Fraction in Bone Marrow and Muscle: Repeatability and Reproducibility Across Field Strength and Protocol

Primary: Acquisition & Reconstruction - Quantitative Imaging: spine, MSK, others
Secondary: Contrast Mechanisms - Fat & Fat/Water Separation
566-06-014 · Quantitative Outcome Measures in MSK MRI · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row G
Keywords: Skeletal Muscle Repeatability and reproducibility PDFF Bone Marrow fat
Accepted
Utsav Shrestha1, Felix Schön 1,2, Jiayi Tang1,3, Ali Pirasteh1,3, Scott B Reeder1,3,4,5,6, Diego Hernando1,3,4,7
1Department of Radiology, University of Wisconsin - Madison, Madison, United States of America
2Institute and Polyclinic for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Carl Gustav Carus Dresden, TU Dresden, Dresden, Germany
3Department of Medical Physics, University of Wisconsin - Madison, Madison, United States of America
4Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, United States of America
5Department of Medicine, University of Wisconsin - Madison, Madison, United States of America
6Department of Emergency Medicine, University of Wisconsin - Madison, Madison, United States of America
7Department of Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, United States of America
Presenting Author: Felix Schön

Synopsis

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References

1. Starekova J, Hernando D, Pickhardt PJ, Reeder SB. Quantification of liver fat content with CT and MRI: State of the art. Radiology. 2021;301(2):250-262. doi:10.1148/radiol.2021204288 [doi]
2. Bray T, Chouhan MD, Punwani S, Bainbridge A, Hall-Craggs MA. Fat Fraction Mapping Using Magnetic Resonance Imaging: Insight into Pathophysiology. Vol 90.; 2018. https://academic.oup.com/bjr/article/91/1089/20170344/7451846.
3. Yokoo T, Serai SD, Pirasteh A, et al. Linearity, bias, and precision of hepatic proton density fat fraction measurements by using MR imaging: A meta-analysis. Radiology. 2018;286(2):486-498. doi:10.1148/radiol.2017170550 [doi]
4. Idilman IS, Yildiz AE, Karaosmanoglu AD, Ozmen MN, Akata D, Karcaaltincaba M. Proton density fat fraction: magnetic resonance imaging applications beyond the liver. Diagnostic and Interventional Radiology. 2022;28(1):83-91. doi:10.5152/dir.2021.21845 [doi]
5. Karampinos DC, Ruschke S, Dieckmeyer M, et al. Modeling of T2* decay in vertebral bone marrow fat quantification. NMR Biomed. 2015;28(11):1535-1542. doi:10.1002/nbm.3420 [doi]
6. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med. 1997;37(4):484-493. doi:10.1002/mrm.1910370403 [doi]
7. Krššák M, Lindeboom L, Schrauwen-Hinderling V, et al. Proton magnetic resonance spectroscopy in skeletal muscle: Experts’ consensus recommendations. NMR Biomed. 2021;34(5). doi:10.1002/nbm.4266 [doi]
8. Hernando D, Sharma SD, Aliyari Ghasabeh M, et al. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat–water phantom. Magn Reson Med. 2017;77(4):1516-1524. doi:10.1002/mrm.26228 [doi]
9. Schmeel FC, Vomweg T, Träber F, et al. Proton density fat fraction MRI of vertebral bone marrow: Accuracy, repeatability, and reproducibility among readers, field strengths, and imaging platforms. Journal of Magnetic Resonance Imaging. 2019;50(6):1762-1772. doi:10.1002/jmri.26748 [doi]
10. Zhang Y, Zhou Z, Wang C, et al. Reliability of measuring the fat content of the lumbar vertebral marrow and paraspinal muscles using MRI mDIXON-quant sequence. Diagnostic and Interventional Radiology. 2018;24(5):302-307. doi:10.5152/dir.2018.17323 [doi]
11. Bainbridge A, Bray TJP, Sengupta R, Hall-Craggs MA. Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms. Journal of Magnetic Resonance Imaging. 2020;52(1):298-306. doi:10.1002/jmri.27039 [doi]
12. Grimm A, Meyer H, Nickel MD, et al. Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification. Eur J Radiol. 2018;103:57-64. doi:10.1016/j.ejrad.2018.04.011 [doi]
13. Karampinos DC, Ruschke S, Dieckmeyer M, et al. Modeling of T2* decay in vertebral bone marrow fat quantification. NMR Biomed. 2015;28(11):1535-1542. doi:10.1002/nbm.3420 [doi]
14. Karampinos DC, Melkus G, Baum T, Bauer JS, Rummeny EJ, Krug R. Bone marrow fat quantification in the presence of trabecular bone: Initial comparison between water-fat imaging and single-voxel MRS. Magn Reson Med. 2014;71(3):1158-1165. doi:10.1002/mrm.24775 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-06-014