Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-007 / 352-03-007 ISMRM Abstract

Age-Associated Changes in Cerebrospinal Fluid Outflow Patterns Quantified with Time-SLIP MRI

Primary: Neuro - Aging
Secondary: Neuro - Other Neurodegeneration
352-03-007 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-007 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Cerebrospinal fluid Cerebrospinal fluid flow Glymphatic system (GS)
Accepted
Vadim Malis 1, Hyena Jung1,2, Yoshiki Kuwatsuru1,3, Won Bae1, Mitsue MIYAZAKI1
1Radiology, University of California, San Diego, United States of America
2Radiology, Korea University Guro Hospital, Seoul, Korea, Republic of
3Department of Radiology, Juntendo University, Tokyo, Japan
Presenting Author: Vadim Malis

Synopsis

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References

1. Yamada S, Miyazaki M, Kanazawa H, et al. Visualization of Cerebrospinal Fluid Movement with Spin Labeling at MR Imaging: Preliminary Results in Normal and Pathophysiologic Conditions. Radiology. 2008;249(2):644-652. doi:10.1148/radiol.2492071985 [doi]
2. Malis V, Miyazaki M. Intrinsic CSF Outflow: MRI evidence for Distinct Flow Mechanisms. #00304 Submitted for ISMRM 2026.
3. Malis V, Bae WC, Yamamoto A, McEvoy LK, McDonald MA, Miyazaki M. Age-related Decline of Intrinsic Cerebrospinal Fluid Outflow in Healthy Humans Detected with Non-contrast Spin-labeling MR Imaging. Magn Reson Méd Sci. 2024;23(1):66-79. doi:10.2463/mrms.mp.2022-0117 [doi]
4. Miyazaki M, Malis V, Yamamoto A, et al. Physical Exercise Alters Egress Pathways for Intrinsic CSF Outflow: An Investigation Performed with Spin-labeling MR Imaging. Magn Reson Méd Sci. 2024;23(2):171-183. doi:10.2463/mrms.mp.2023-0005 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-007