Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-005 ISMRM Abstract

Comparative evaluation of hyperpolarized [13C]pyruvate and [13C]lactate for imaging neuronal and glioma metabolism

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Contrast Mechanisms - Molecular Imaging
465-01-005 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Glioma 1-13C Pyruvate Lactate 3.0T Hyperpolarized MRI
Accepted
Jun Chen 1, Jaideep Chaudhary1, Zohreh Erfani1, Sarah Al Nemri1, Erik J Plautz2, Erin H Seeley3, Xiaodong Wen1, Brenda L Bartnik-Olson4, Ian R Corbin1,5,6, Jae Hong Park1,6,7,8
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Neurology, University of Texas Southwestern Medical Center, Dallas, United States of America
3Department of Chemistry, The University of Texas at Austin, Austin, United States of America
4Department of Radiology, Loma Linda University, Loma Linda, United States of America
5Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States of America
6Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States of America
7Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, United States of America
8Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, United States of America
Presenting Author: Jun Chen

Synopsis

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References

1. Bélanger, M., Allaman, I. & Magistretti, P. J. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14, 724-738 (2011). https://doi.org/10.1016/j.cmet.2011.08.016 [doi]
2. Park, J. M. et al. Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging. Neuro Oncol 15, 433-441 (2013). https://doi.org/10.1093/neuonc/nos319 [doi]
3. Chen, J., Hackett, E. P., Kovacs, Z., Malloy, C. R. & Park, J. M. Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1-(13) C]-l-lactate. Magn Reson Med 85, 1175-1182 (2021). https://doi.org/10.1002/mrm.28489 [doi]
4. Hackett, E. P. et al. Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-(13) C]pyruvate. Magn Reson Med 90, 2432-2442 (2023). https://doi.org/10.1002/mrm.29794 [doi]
5. Park, J. M. et al. Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment. NMR Biomed 29, 650-659 (2016). https://doi.org/10.1002/nbm.3509 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-005