Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
651-02-013 / 651-02-013 ISMRM Abstract

Characterizing heterogeneity in white matter microstructure among patients with obsessive-compulsive disorder

Primary: Neuro - White Matter
Secondary: Diffusion - Microstructure
651-02-013 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
651-02-013 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: White Matter Clustering analysis Microstructural abnormalities Pharmacotherapy
Accepted
Shuangwei Chai 1,2, Hailong Li1,2, Zilin Zhou1,2, Jiaxin Jiang3,4, Lingxiao Cao1,2, Yuanyuan Luo1,2, Bin Li4, Xiaoqi Huang1,2,5
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, China
2Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China
3Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, China
4Mental Health Center, West China Hospital, Sichuan University, Chengdu, China
5Xiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China
Presenting Author: Shuangwei Chai

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Stein DJ, Costa DLC, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, van den Heuvel OA, Simpson HB. Obsessive-compulsive disorder. Nat Rev Dis Primers. 2019 Aug 1;5(1):52. doi: 10.1038/s41572-019-0102-3. Erratum in: Nat Rev Dis Primers. 2024 Oct 16;10(1):79. doi: 10.1038/s41572-024-00569-z. PMID: 31371720; PMCID: PMC7370844. [doi] [pmid]
2. Ding Z, Shang T, Ding Z, Yang X, Qi J, Qin X, Chen Y, Lv D, Li T, Ma J, Zhan C, Xiao J, Sun Z, Wang N, Yu Z, Li C, Li P. Two multimodal neuroimaging subtypes of obsessive-compulsive disorder disclosed by semi-supervised machine learning. J Affect Disord. 2024 Jun 1;354:293-301. doi: 10.1016/j.jad.2024.03.011. Epub 2024 Mar 15. PMID: 38494136. [doi] [pmid]
3. Vriend C, de Joode NT, Pouwels PJW, Liu F, Otaduy MCG, Pastorello B, Robertson FC, Ipser J, Lee S, Hezel DM, van Meter PE, Batistuzzo MC, Hoexter MQ, Sheshachala K, Narayanaswamy JC, Venkatasubramanian G, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, Stein DJ, Wall M, Simpson HB, van den Heuvel OA. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Mol Psychiatry. 2024 Apr;29(4):1033-1045. doi: 10.1038/s41380-023-02390-8. Epub 2024 Jan 16. PMID: 38228890; PMCID: PMC11176057. [doi] [pmid]
4. Varol E, Sotiras A, Davatzikos C; Alzheimer's Disease Neuroimaging Initiative. HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework. Neuroimage. 2017 Jan 15;145(Pt B):346-364. doi: 10.1016/j.neuroimage.2016.02.041. Epub 2016 Feb 23. PMID: 26923371; PMCID: PMC5408358. [doi] [pmid]
5. Wasserthal J, Neher P, Maier-Hein KH. TractSeg - Fast and accurate white matter tract segmentation. Neuroimage. 2018 Dec;183:239-253. doi: 10.1016/j.neuroimage.2018.07.070. Epub 2018 Aug 4. PMID: 30086412. [doi] [pmid]
6. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003 Nov;20(3):1714-22. doi: 10.1016/j.neuroimage.2003.07.005. PMID: 14642481. [doi] [pmid]
7. Shephard E, Stern ER, van den Heuvel OA, Costa DLC, Batistuzzo MC, Godoy PBG, Lopes AC, Brunoni AR, Hoexter MQ, Shavitt RG, Reddy YCJ, Lochner C, Stein DJ, Simpson HB, Miguel EC. Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder. Mol Psychiatry. 2021 Sep;26(9):4583-4604. doi: 10.1038/s41380-020-01007-8. Epub 2021 Jan 7. PMID: 33414496; PMCID: PMC8260628. [doi] [pmid]
8. Makris N, Preti MG, Asami T, Pelavin P, Campbell B, Papadimitriou GM, Kaiser J, Baselli G, Westin CF, Shenton ME, Kubicki M. Human middle longitudinal fascicle: variations in patterns of anatomical connections. Brain Struct Funct. 2013 Jul;218(4):951-68. doi: 10.1007/s00429-012-0441-2. Epub 2012 Jul 11. PMID: 22782432; PMCID: PMC3500586. [doi] [pmid]
9. Nakajima R, Kinoshita M, Shinohara H, Nakada M. The superior longitudinal fascicle: reconsidering the fronto-parietal neural network based on anatomy and function. Brain Imaging Behav. 2020 Dec;14(6):2817-2830. doi: 10.1007/s11682-019-00187-4. PMID: 31468374. [doi] [pmid]
10. Çavdar S, Esen Aydın A, Algin O, Aydoğmuş E. Fiber dissection and 3-tesla diffusion tensor tractography of the superior cerebellar peduncle in the human brain: emphasize on the cerebello-hypthalamic fibers. Brain Struct Funct. 2020 Jan;225(1):121-128. doi: 10.1007/s00429-019-01985-8. Epub 2019 Nov 27. PMID: 31776651. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/651-02-013