Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-06-012 ISMRM Abstract

Revealing gray and white matter microstructure differences in subjective cognitive decline using NODDI

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Alzheimer's Disease
362-06-012 · Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row C
Keywords: Alzheimer's Disease Gray Matter White Matter Neurite orientation dispersion and density imaging Subjective cognitive decline
Accepted
Shuai Lin 1, jianxiu lian2, Wei Wang3
1MRI, First Affiliated Hospital of Harbin Medcial University, China
2Philips Healthcare (Beijing), Beijing, China
3First Affiliated Hospital of Harbin Medcial University, China
Presenting Author: Shuai Lin

Synopsis

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References

1. 2024 Alzheimer's disease facts and figures. Alzheimers Dement. 2024;20(5):3708-3821.
2. Zhou C, Jeryous Fares B, Thériault K, et al. Subjective cognitive decline and objective cognitive performance in older adults: A systematic review of longitudinal and cross-sectional studies. J Neuropsychol. 2025;19(1):98-114.
3. Cai Y, Fang L, Li A, et al. Educational attainment, Aβ, tau, and structural brain reserve in Alzheimer's disease. Alzheimers Dement. 2025;21(2):e14400.
4. Wang X, Huang W, Su L, et al. Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease. Mol Neurodegener. 2020;15(1):55.
5. Zhang W, Zhang C, Zhao J, et al. Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First-Episode, Treatment-Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study. Brain Behav. 2025;15(3):e70416.
6. Palacios EM, Owen JP, Yuh EL, et al. The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study. Sci Adv. 2020;6(32):eaaz6892.
7. Vogt NM, Hunt JF, Adluru N, et al. Cortical Microstructural Alterations in Mild Cognitive Impairment and Alzheimer's Disease Dementia. Cereb Cortex. 2020;30(5):2948-2960.
8. Daducci A, Canales-Rodríguez EJ, Zhang H, Dyrby TB, Alexander DC, Thiran JP. Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data. Neuroimage. 2015;105:32-44.
9. Chen Z, Xie Q, Wang J, et al. Mapping grey matter and cortical thickness alterations associated with subjective cognitive decline and mild cognitive impairment among rural-dwelling older adults in China: A population-based study. Neuroimage Clin. 2024;44:103691.
10. Riverol M, Ríos-Rivera MM, Imaz-Aguayo L, et al. Structural neuroimaging changes associated with subjective cognitive decline from a clinical sample. Neuroimage Clin. 2024;42:103615.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-06-012