Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
370-01-008 ISMRM Abstract

Multiparametric qMRI mapping of myelin dynamics in multiple sclerosis: link with brain atrophy and disability progression

Primary: Analysis Methods - Classification and Prediction
Secondary: Neuro - Multiple Sclerosis
370-01-008 · All About Neuroinflammation · Monday, 11 May, 8:20 AM–9:15 AM · Traditional Posters | Exhibition Hall
Keywords: Analysis/Processing Disease progression Myelin mapping Quantitative MRI (qMRI) Multiple Sclerosis brain
Accepted
Sara Alampi1, Giordano Gentile1,2, Alessandro Cagol3,4,5,6, Ludovico Luchetti1,2, Mario Ocampo-Pineda 4,5,6, Giuseppe Battaglia1, Alessia Bianchi1, Valentina Damato7,8, Ludwig Kappos5,6, Cristina Granziera4,5,6,9,10, Nicola De Stefano1, Rosa Cortese1, Marco Battaglini1,2
1Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
2Siena Imaging, Siena, Italy
3Department of Health Sciences, University of Genova, Genova, Italy
4Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
5Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, Switzerland
6Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland., Switzerland
7NEUROFARBA, University of Florence, Florence, Italy
8Careggi University Hospital of Florence, Firenze, Italy
9Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland., Switzerland
10Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland., Switzerland
Presenting Author: Mario Ocampo-Pineda

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References

1. Smith SM, Zhang Y, Jenkinson M, Chen J, Matthews PM, Federico A, De Stefano N. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage. 2002 Sep;17(1):479-89. doi: 10.1006/nimg.2002.1040. PMID: 12482100 [doi] [pmid]
2. https://www.fmrib.ox.ac.uk/fsl/; atlas: HarvardOxford-sub-maxprob-thr25-1mm
3. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001 Jan;20(1):45-57. doi: 10.1109/42.906424. PMID: 11293691. [doi] [pmid]
4. Bodini B, Veronese M, García-Lorenzo D, Battaglini M, Poirion E, Chardain A, Freeman L, Louapre C, Tchikviladze M, Papeix C, Dollé F, Zalc B, Lubetzki C, Bottlaender M, Turkheimer F, Stankoff B. Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis. Ann Neurol. 2016 May;79(5):726-738. doi: 10.1002/ana.24620. PMID: 26891452; PMCID: PMC5006855. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/370-01-008