Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
570-08-225 ISMRM Abstract

Investigating the effect of focused ultrasound on relaxation and oxygenation in an intracerebral haemorrhage stroke rat model

Primary: Preclinical Animal & in vitro MR - Small Animals
Secondary: Physics & Engineering - Multimodal
570-08-225 · Preclinical · Wednesday, 13 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: Focused Ultrasound Oxygen extraction fraction Stroke rat model
Accepted
Fabian Küppers 1, Ezequiel Farrher2, Kuan-Hung Cho3, Sheng-Min Huang4, Yi-Hua Hsu5, Ming-Jye Chen6, Chia-Ching Pan6, Hsin-Yun Chang6, Chang-Hoon Choi2, N. Jon Shah2,7,8,9, Abel Po-Hao Huang5, Gin-Shin Chen6,10,11, Li-Wei Kuo6,12
1Forschungszentrum Juelich, Juelich, Germany
2Institute of Neuroscience and Medicine 4, Forschungszentrum Juelich, Juelich, Germany
3Department of Electronic Engineering, National United University, Miaoli, Taiwan
4Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan
5Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
6Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan
7Institute of Neuroscience and Medicine 11, JARA, Forschungszentrum Juelich, Juelich, Germany
8Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany
9JARA - BRAIN - Translational Medicine, Aachen, Germany
10Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
11Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung City, Taiwan
12Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan
Presenting Author: Fabian Küppers

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References

1. C. Preibisch et al., “Characterizing hypoxia in human glioma: A simultaneous multimodal MRI and PET study,” NMR Biomed., vol. 30, no. 11, p. e3775, Nov. 2017, doi: 10.1002/nbm.3775. [doi]
2. X. He and D. A. Yablonskiy, “Quantitative BOLD: Mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: Default state,” Magn. Reson. Med., vol. 57, no. 1, pp. 115–126, 2007, doi: 10.1002/mrm.21108. [doi]
3. A. P. Fan et al., “Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke,” J. Cereb. Blood Flow Metab., vol. 40, no. 3, pp. 539–551, Mar. 2020, doi: 10.1177/0271678X19827944. [doi]
4. T.-C. Lin et al., “Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study,” Front. Cell. Neurosci., vol. 17, p. 1170251, 2023, doi: 10.3389/fncel.2023.1170251. [doi]
5. K.-H. Cho et al., “Development, integration and use of an ultra-high-strength gradient system on a human-size 3 T magnet for small animal MRI,” PloS One, vol. 14, no. 6, p. e0217916, 2019, doi: 10.1371/journal.pone.0217916. [doi]
6. S.-Y. Huang, C.-E. Ko, G.-S. Chen, I.-F. Chung, and F.-Y. Yang, “Focused Ultrasound Simultaneous Irradiation/MRI Imaging, and Two-Stage General Kinetic Model,” PLOS ONE, vol. 9, no. 6, p. e100280, Jun. 2014, doi: 10.1371/journal.pone.0100280. [doi]
7. P.-C. Chu et al., “Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex,” Int. J. Mol. Sci., vol. 24, no. 3, Art. no. 3, Jan. 2023, doi: 10.3390/ijms24032578. [doi]
8. M.-J. Chen et al., “Design, setup and establishment of a brain stimulation system and technique for hybrid 3 T MR-FUS in in vivo rats,” presented at the 2025 ISMRM & ISMRT Annual Meeting, Honolulu, Hawaii, USA, p. 1527. doi: 10.58530/2025/1527. [doi]
9. E. Farrher et al., “Spatiotemporal characterisation of ischaemic lesions in transient stroke animal models using diffusion free water elimination and mapping MRI with echo time dependence,” NeuroImage, vol. 244, p. 118605, Dec. 2021, doi: 10.1016/j.neuroimage.2021.118605. [doi]
10. X. He, M. Zhu, and D. A. Yablonskiy, “Validation of Oxygen Extraction Fraction Measurement by qBOLD Technique,” Magn. Reson. Med., vol. 60, no. 4, pp. 882–888, Oct. 2008, doi: 10.1002/mrm.21719. [doi]
11. F. Küppers, S. D. Yun, and N. J. Shah, “Development of a novel 10-echo multi-contrast sequence based on EPIK to deliver simultaneous quantification of T2 and T2* with application to oxygen extraction fraction,” Magn. Reson. Med., vol. 88, no. 4, pp. 1608–1623, Oct. 2022, doi: 10.1002/mrm.29305. [doi]

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http://echo.ismrm.org/p/ISMRM2026/570-08-225