401-04-009 ISMRM Abstract

MRI/S reveals metabolic changes in muscle, liver, and fat after 3-month complex lifestyle intervention in obese adults

Primary: Cross-Organ

Secondary: Body - Metabolism

401-04-009 · Metabolism · Tuesday, 12 May, 4:00 PM–5:50 PM · Hall 1A

Keywords: Liver Magnetic Resonance Imaging (MRI) Obesity Muscle Metabolism Magnetic Resonance Spectroscopy

Accepted

Radka Klepochová^1,2,3,4, Lucia Slobodová², Ivica Just^1,3, Petronela Forišek Paulová², Oksana Mytiai^2,5, Ali Amiri², Petra Vadovičová², Jana Kubíčková², Daria Barková², Patrik Konrády², Viera Litváková², Peter Minárik², Pavol Szomolanyi^4,6, Martin Krssak ^1,3, Jozef Ukropec², Barbara Ukropcová^2,5

¹Clinical Division of Internal Medicine III, Vienna, Austria

²Institute of Experimental Endocrinology, Biomedical Research Center, Bratislava, Slovakia

³Medical University of Vienna, Vienna, Austria

⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, Slovakia

⁵Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia

⁶Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria

Presenting Author: Martin Krssak

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References

1. Lanza IR, et al. Mitochondrial metabolic function assessed in vivo and in vitro. Current Opinion in Clinical Nutrition and Metabolic Care. 2010;13(5):511–517. DOI: 10.1097/MCO.0b013e32833cc93d [doi]

2. Winhofer Y, et al. Hepatic rather than cardiac steatosis relates to glucose intolerance in women with prior gestational diabetes. PLoS One. 2014;9(3):e91607. DOI: 10.1371/journal.pone.0091607 [doi]

3. Machann J, et al. Fraction of unsaturated fatty acids in visceral adipose tissue (VAT) is lower in subjects with high total VAT volume – a combined ¹H-MRS and volumetric MRI study in male subjects. NMR in Biomedicine. 2012;25(6):1030–1036. DOI: 10.1002/nbm.2849 [doi]

4. Kemp GJ, et al. Quantification of skeletal muscle mitochondrial function by ³¹P magnetic resonance spectroscopy techniques: a quantitative review. Acta Physiologica (Oxford). 2015;213(1):107–144. DOI: 10.1111/apha.12307 [doi]

5. Ukropec J, et al. Adipose tissue and skeletal muscle plasticity modulates metabolic health. Cellular and Molecular Life Sciences. 2008;65(13):1924–1938. DOI: 10.1007/s00018-008-8019-6 [doi]

6. Krššák M, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a ¹H-NMR spectroscopy study. Diabetologia. 1999;42(1):113–116. DOI: 10.1007/s001250051123 [doi]

7. Klepochová R, et al. Detection and alterations of acetylcarnitine in human skeletal muscles by ¹H-MRS at 7 T. Investigative Radiology. 2016;51(7):457–463. DOI: 10.1097/RLI.0000000000000355 [doi]

8. Klepochová R, et al. ¹H and ³¹P MRS interleaved with high time resolution reveals closely matching creatine CH₂ and PCr dynamics during exercise. NMR in Biomedicine. 2025;38(10):e70132. DOI: 10.1002/nbm.70132 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/401-04-009