Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-03-005 ISMRM Abstract

MR Elastography Reveals Hormone-Related Hippocampal Mechanical Property Changes During the Menopausal Transition

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Neuro - Aging
301-03-005 · Neuroimaging and Spectroscopy in Experimental Models · Monday, 11 May, 1:50 PM–3:40 PM · Hall 1A
Keywords: Hippocampus Magnetic Resonance Elastography Menopause model Sex hormones
Accepted
Sabrina S Vander Wiele 1, Katrina Milbocker1, Meggan K Bischoff2, Kaelin M Penna3, Anna Y Klintsova2, Curtis L Johnson1
1Biomedical Engineering, University of Delaware, Newark, United States of America
2Psychological and Brain Sciences, University of Delaware, Newark, United States of America
3Biological Sciences, University of Delaware, Newark, United States of America
Presenting Author: Sabrina S Vander Wiele

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Mosconi, L., Nerattini, M., Matthews, D. C., Jett, S., Andy, C., Williams, S., Yepez, C. B., Zarate, C., Carlton, C., Fauci, F., Ajila, T., Pahlajani, S., Andrews, R., Pupi, A., Ballon, D., Kelly, J., Osborne, J. R., Nehmeh, S., Fink, M., … Brinton, R. D. (2024). In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology. Scientific Reports, 14(1), 12680. https://doi.org/10.1038/s41598-024-62820-7 [doi]
2. Mosconi, L., Rahman, A., Diaz, I., Wu, X., Scheyer, O., Hristov, H. W., Vallabhajosula, S., Isaacson, R. S., De Leon, M. J., & Brinton, R. D. (2018). Increased Alzheimer’s risk during the menopause transition: A 3-year longitudinal brain imaging study. PLOS ONE, 13(12), e0207885. https://doi.org/10.1371/journal.pone.0207885 [doi]
3. McCarthy, M., & Raval, A. P. (2020). The peri-menopause in a woman’s life: A systemic inflammatory phase that enables later neurodegenerative disease. Journal of Neuroinflammation, 17(1), 317. https://doi.org/10.1186/s12974-020-01998-9 [doi]
4. Kim, G.-W., Park, K., & Jeong, G.-W. (2018). Effects of Sex Hormones and Age on Brain Volume in Post-Menopausal Women. The Journal of Sexual Medicine, 15(5), 662–670. https://doi.org/10.1016/j.jsxm.2018.03.006 [doi]
5. Su, J., Sripanidkulchai, K., Hu, Y., Wyss, J. M., & Sripanidkulchai, B. (2012). The Effect of Ovariectomy on Learning and Memory and Relationship to Changes in Brain Volume and Neuronal Density. International Journal of Neuroscience, 122(10), 549–559. https://doi.org/10.3109/00207454.2012.690795 [doi]
6. Milbocker, K. A., Williams, L. T., Vander Wiele S.S. , Zarate E. D. , Schwarb H., Klintsova A. Y., Johnson C. L. (2025). Hippocampal viscosity is increased when estrogen is low in female rats scanned with MR elastography. International Society of Magnetic Resonance in Medicine. Abstract #4924.
7. Hiscox, L. V., Schwarb, H., McGarry, M. D. J., & Johnson, C. L. (2021). Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage, 232, 117889. https://doi.org/10.1016/j.neuroimage.2021.117889 [doi]
8. Milbocker, K. A., Williams, L. T., Caban‐Rivera, D. A., Smith, I. F., Kurtz, S., McGarry, M. D. J., Wattrisse, B., Van Houten, E. E. W., Johnson, C. L., & Klintsova, A. Y. (2024). Magnetic resonance elastography captures a transient benefit of exercise intervention on forebrain stiffness in a rat model of fetal alcohol spectrum disorders. Alcohol, Clinical and Experimental Research, 48(3), 466–477. https://doi.org/10.1111/acer.15265 [doi]
9. McGarry, M. D. J., Van Houten, E. E. W., Johnson, C. L., Georgiadis, J. G., Sutton, B. P., Weaver, J. B., & Paulsen, K. D. (2012). Multiresolution MR elastography using nonlinear inversion. Medical Physics, 39(10), 6388–6396. https://doi.org/10.1118/1.4754649 [doi]
10. Kurtz, S., Wattrisse, B., & Van Houten, E. E. W. (2024). Minimizing Measurement-Induced Errors in Viscoelastic MR Elastography. IEEE Transactions on Medical Imaging, 43(3), 1138–1148. https://doi.org/10.1109/TMI.2023.3329293 [doi]
11. Maki, P. M., & Jaff, N. G. (2022). Brain fog in menopause: A health-care professional’s guide for decision-making and counseling on cognition. Climacteric, 25(6), 570–578. https://doi.org/10.1080/13697137.2022.2122792 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-03-005