301-03-007 ISMRM Abstract

Common pallidal structural remodeling underlying diverse antidepressant actions revealed by mouse VBM

Primary: Neuro - Psychiatric Disorders

Secondary: Preclinical Animal & in vitro MR - Other Preclinical

301-03-007 · Neuroimaging and Spectroscopy in Experimental Models · Monday, 11 May, 1:50 PM–3:40 PM · Hall 1A

Keywords: Depression Voxel-based morphometry Antidepressant Pallidum Synapse

Accepted

Yoshifumi Abe ¹, Kenji Tanaka¹

¹Keio University School of Medicine, Tokyo, Japan

Presenting Author: Yoshifumi Abe

Synopsis

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References

1. Jakobsen JC, Katakam KK, Schou A, Hellmuth SG, Stallknecht SE, Leth-Moller K et al. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis. BMC Psychiatry 2017; 17(1): 58.

2. Abdallah CG, Sanacora G, Duman RS, Krystal JH. Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics. Annu Rev Med 2015; 66: 509-523.

3. Zarate CJ, Singh J, Carlson P, Brutsche N, Ameli R, Luckenbaugh D et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006; 63(8): 856-864.

4. Gukasyan N, Davis AK, Barrett FS, Cosimano MP, Sepeda ND, Johnson MW et al. Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up. J Psychopharmacol 2022; 36(2): 151-158.

5. Abe Y, Erchinger VJ, Ousdal OT, Oltedal L, Tanaka KF, Takamiya A. Neurobiological mechanisms of electroconvulsive therapy for depression: Insights into hippocampal volumetric increases from clinical and preclinical studies. J Neurochem 2024; 168(9): 1738-1750.

6. Nakano Y, Tanaka KF, Abe Y. Combination method of macroscopic imaging with MRI and microscopic imaging with super resolution microscopy for brain microstructure analysis. Anat Sci Int 2025.

7. Tsugawa S, Honda S, Noda Y, Wannan C, Zalesky A, Tarumi R et al. Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia. Schizophr Bull 2023.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-03-007