Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-011 ISMRM Abstract

Quantitative MRI Evaluation of Glymphatic–Lymphatic Clearance by Low-intensity Focused Ultrasound in Non-human Primate

Primary: Neuro - Neurofluids
Secondary: Neuro - Neuromodulation
663-03-011 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Focused Ultrasound Glymphatic system Brain clearance Meningeal lymphatic Non-invasive Neuromodulation
Accepted
Hyochul Lee 1,2,3, Taewon Choi4, Jun-Hee Kim2,5, Taekyu Jang1,2, Seoyun Chang4, Ok Kyu Park1,2,3, Seungryeol Park1,3, Bowon Lee1,3, Roh-Eul Yoo1,2, Jinhyoung Park4, Seung Hong Choi1,2,3
1Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Republic of
2Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
3Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea, Republic of
4Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of
5Medical Research Center, Seoul National University, Seoul, Korea, Republic of
Presenting Author: Hyochul Lee

Synopsis

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References

1. Iliff JJ, Wang M, Liao Y, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med. 2012;4(147). doi:10.1126/scitranslmed.3003748. [doi]
2. Ahn JH, Cho H, Kim JH, et al. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature. 2019;572(7767):62-66. doi:10.1038/s41586-019-1419-5. [doi]
3. Lee H, Choi SH, Anzai Y. Glymphatic MRI techniques in sleep and neurodegenerative diseases. Current Opinion in Pulmonary Medicine. 2022;28(6):499-510. doi:10.1097/MCP.0000000000000923. [doi]
4. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018 Nov;17(11):1016-1024. doi: 10.1016/S1474-4422(18)30318-1. [doi]
5. Lee S, Yoo RE, Choi SH, et al. Contrast-enhanced MRI T1 Mapping for Quantitative Evaluation of Putative Dynamic Glymphatic Activity in the Human Brain in Sleep-Wake States. Radiology. 2021;300(3):661-668. doi:10.1148/radiol.2021203784. [doi]
6. Kim JH, Yoo RE, Choi SH, Park SH. Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI. Fluids Barriers CNS. 2023;20(1):37. doi:10.1186/s12987-023-00446-z. [doi]
7. Sanz-Morales E, Melero H. Advances in the fMRI analysis of the default mode network: a review. Brain Struct Funct. 2024 Dec 30;230(1):22. doi: 10.1007/s00429-024-02888-z. PMID: 39738718. [doi] [pmid]
8. Yoo RE, Kim JH, Moon HY, Park JY, Cheon S, Shin HS, Han D, Kim Y, Park SH, Choi SH. Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans. Nat Commun. 2025 Apr 9;16(1):3360. doi: 10.1038/s41467-025-58726-1. [doi]
9. Van Essen DC, Dierker DL. Surface-based and probabilistic atlases of primate cerebral cortex. Neuron. 2007 Oct 25;56(2):209-25. doi: 10.1016/j.neuron.2007.10.015. [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-03-011