Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-009 / 352-03-009 ISMRM Abstract

Non-invasive Trigeminal Nerve Stimulation for Brain Clearance: CSF Modulation Changes Measured by Low-b DTI and DTI-ALPS

Primary: Neuro - Neurofluids
Secondary: Neuro - Neuromodulation
352-03-009 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-009 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Neurofluids DTI-ALPS Diffusion Tensor Imaging (DTI) Glymphatic system (GS) FMRI and neuromodulation
Accepted
Robert Moskwa 1, Kevin Cheng2, Walter F Block1,3, Keith Kozma3, Christopher Minar4, Rasmus Birn5, James Trevathan2, Samuel A Hurley6, Kevin M Johnson1,6, VEENA A NAIR6, Vivek Prabhakaran6, Aaron J Suminski2, Patrick Belton2, Justin Williams3, Kip Ludwig2
1Department of Medical Physics, University of Wisconsin - Madison, Madison, United States of America
2Department of Neurological Surgery, University of Wisconsin - Madison, Madison, United States of America
3Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, United States of America
4NeuraWorx, Excelsior, United States of America
5Department of Psychiatry, University of Wisconsin - Madison, Madison, United States of America
6Department of Radiology, University of Wisconsin - Madison, Madison, United States of America
Presenting Author: Robert Moskwa

Synopsis

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References

1. Sun YR, Lv QK, Liu JY, Wang F, Liu CF. New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases. Neurobiol Dis. 2025 Feb;205:106791. doi: 10.1016/j.nbd.2025.106791. Epub 2025 Jan 6. PMID: 39778750. [doi] [pmid]
2. Cai Y, Zhang Y, Leng S, Ma Y, Jiang Q, Wen Q, Ju S, Hu J. The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle. Neurobiol Dis. 2024 Mar;192:106426. doi: 10.1016/j.nbd.2024.106426. Epub 2024 Feb 7. PMID: 38331353. [doi] [pmid]
3. Moskwa, R., Cheng, K., Block, W., Minar, C., Williams, J., & Ludwig, K. First in human evaluation of non-invasive cranial nerve stimulation: DTI measures change in arterial perivascular space and nearby parenchyma [Abstract 0466]. ISMRM & ISMRT 2025 Annual Meeting & Exhibition; 11 May 2025; Honolulu, Hawai’i, USA.
4. Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Jpn J Radiol. 2017 Apr;35(4):172-178. doi: 10.1007/s11604-017-0617-z. Epub 2017 Feb 14. PMID: 28197821. [doi] [pmid]
5. Harrison IF, Siow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI. Elife. 2018 Jul 31;7:e34028. doi: 10.7554/eLife.34028. PMID: 30063207; PMCID: PMC6117153. [doi] [pmid]
6. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23 Suppl 1:S208-19. doi: 10.1016/j.neuroimage.2004.07.051. PMID: 15501092. [doi] [pmid]
7. Ringstad G. Glymphatic imaging: a critical look at the DTI-ALPS index. Neuroradiology. 2024 Feb;66(2):157-160. doi: 10.1007/s00234-023-03270-2. Epub 2024 Jan 10. PMID: 38197950. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-009