Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-03-015 Registered Abstract

The impact of reperfusion onset on QQ-derived oxygen metabolism in experimental ischemic stroke

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Preclinical Animal & in vitro MR - Small Animals
463-03-015 · Metabolic Parameters in Stroke · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Oxygen extraction fraction Metabolic imaging Animal MRI Stroke rat model Ischemic Stroke
Accepted
Bart Franx 1, Annette Van der Toorn1, Lois A Chin Joe Kin1, Gene Kim2,3,4,5, Yi Wang3,6,7,8, Junghun Cho9,10, Rick M Dijkhuizen1
1Translational Neuroimaging group, Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands
2Weill Cornell Medicine, New York, United States of America
3Department of Radiology, Weill Cornell Medicine, New York, United States of America
4Department of Radiology, Weill Cornell Medical College, New York, United States of America
5Department of Radiology, NYU Grossman School of Medicine, New York, United States of America
6Radiology, Weill Cornell Medicine, New York, United States of America
7Biomedical Engineering, Cornell University, Ithaca, United States of America
8Department Radiology & Biomedical Engineering, Weill Cornell Medicine, Cornell University, New York, United States of America
9George Washington University, Washington, United States of America
10Biomedical Engineering, George Washington University, Washington, United States of America
Presenting Author: Bart Franx

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References

1. Deng G, Xiao J, Yu H, Chen M, Shang K, Qin C, Tian DS. Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis. Journal of NeuroInterventional Surgery. 2022 Sep 1;14(9):881-5. https://doi.org/10.1136/neurintsurg-2021-017963 [doi]
2. Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA. Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology. 2009 Sep 29;73(13):1066-72. doi:10.1212/WNL.0b013e3181b9c847 [doi]
3. Biondetti E, Cho J, Lee H. Cerebral oxygen metabolism from MRI susceptibility. Neuroimage. 2023 Aug 1;276:120189. https://doi.org/10.1016/j.neuroimage.2023.120189 [doi]
4. Cho J, Kee Y, Spincemaille P, Nguyen TD, Zhang J, Gupta A, Zhang S, Wang Y. Cerebral metabolic rate of oxygen (CMRO2) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level‐dependent imaging (qBOLD). Magnetic resonance in medicine. 2018 Oct;80(4):1595-604. https://doi.org/10.1002/mrm.27135 [doi]
5. Wu D, Zhou Y, Cho J, Shen N, Li S, Qin Y, Zhang G, Yan S, Xie Y, Zhang S, Zhu W. The spatiotemporal evolution of MRI-derived oxygen extraction fraction and perfusion in ischemic stroke. Frontiers in Neuroscience. 2021 Aug 16;15:716031. https://doi.org/10.3389/fnins.2021.716031 [doi]
6. Kataike VM, Desmond PM, Steward C, Campbell BC, Mitchell PJ, Ng F, Venkatraman V. Oxygen extraction fraction changes in ischemic tissue from 24–72 hours to 12 months after successful reperfusion. Journal of Cerebral Blood Flow & Metabolism. 2025 Apr 12:0271678X251333940. doi:10.1177/0271678X251333940 [doi]
7. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. stroke. 1989 Jan;20(1):84-91. https://doi.org/10.1161/01.STR.20.1.84 [doi]
8. Cho J, Spincemaille P, Nguyen TD, Gupta A, Wang Y. Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD. Magnetic resonance in medicine. 2021 Nov;86(5):2635-46. https://doi.org/10.1002/mrm.28875 [doi]

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http://echo.ismrm.org/p/ISMRM2026/463-03-015