405-02-010 ISMRM Abstract

In multiple sclerosis skull TSPO overexpression by 11C-PBR28 MR-PET associates with clinical disability and neurodegeneration

Primary: Neuro - Multiple Sclerosis

Secondary: Neuro - Neuroinflammation

405-02-010 · What's New in Multiple Sclerosis? · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom West

Keywords: Multiple Sclerosis Disease progression Skull PET-MRI

Accepted

Gianluca Corazzolla^1,2,3, Constantina A Treaba^1,4, Mehrbod Mohammadian^1,4, Ludovica Brusaferri^1,5, Valeria Barletta^1,4, Nicole R Zűrcher^1,4, Jacob M Hooker^1,4, Jacob Sloane⁶, Eric Klawiter^4,7, Roberto Bomprezzi⁸, Maria A. Rocca^2,3,9, Massimo Filippi^2,3,9,10,11, Marco L Loggia^1,4,12, Caterina Mainero ^1,4

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

²Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy

³Vita-Salute San Raffaele University, Milan, Italy

⁴Harvard Medical School, Boston, United States of America

⁵Computer Science and Digital Technology, College of Technology and Environment, London South Bank University, London, United Kingdom

⁶Department of Neurology, Beth Israel Deaconess Medical Center, Boston, United States of America

⁷Massachusetts General Hospital, Boston, United States of America

⁸Department of Neurology, UMass Chan Medical School, Worcester, United States of America

⁹Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

¹⁰Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

¹¹Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

¹²Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, United States of America

Presenting Author: Caterina Mainero

Synopsis

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References

1. Herisson F, Frodermann V, Courties G, et al. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. Sep 2018;21(9):1209-1217. doi:10.1038/s41593-018-0213-2 [doi]

2. Shi K, Li H, Chang T, et al. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. Jun 23 2022;185(13):2234-2247 e17. doi:10.1016/j.cell.2022.05.020 [doi]

3. Kolabas ZI, Kuemmerle LB, Perneczky R, et al. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. Aug 17 2023;186(17):3706-3725 e29. doi:10.1016/j.cell.2023.07.009 [doi]

4. Mohammadian M, Efthimiou N, Brusaferri L, et al. Evidence for a role of skull bone marrow in human chronic pain as revealed by TSPO PET imaging. medRxiv. 2025:2025.07.19.25331817. doi:10.1101/2025.07.19.25331817 [doi]

5. Mazzitelli JA, Pulous FE, Smyth LCD, et al. Skull bone marrow channels as immune gateways to the central nervous system. Nat Neurosci. Dec 2023;26(12):2052-2062. doi:10.1038/s41593-023-01487-1 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/405-02-010