Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
567-04-003 ISMRM Abstract

Progressive Reorganization of Cortical Functional Connectivity Gradients in Non-Dialysis Patients With Chronic Kidney Disease

Primary: Brain Function and fMRI - Functional Connectivity
Secondary: Cross-Organ
567-04-003 · Quantitative and Multimodal MRI Biomarkers Across Neurologic and Systemic Disorders · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row H
Keywords: Functional connectivity gradient BOLD-fMRI Chronic Kidney Disease 3T Cognitive decline
Accepted
Siyuan Lu 1, Song'an Shang1, Wenjin Liu2, Daming Shen3, jing Ye1
1Department of Radiology, Northern Jiangsu People’s Hospital, Yangzhou, China
2Department of Nephrology, Northern Jiangsu People’s Hospital, Yangzhou, China
3MR Research China, GE Healthcare, Beijing, China
Presenting Author: Siyuan Lu

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References

1. Capasso G, Franssen CFM, Perna AF, et al. Drivers and mechanisms of cognitive decline in chronic kidney disease. Nature reviews Nephrology. Aug 2025;21(8):536-552. doi:10.1038/s41581-025-00963-0 [doi]
2. Zhang D, Chen Y, Shen J, et al. Static and Dynamic Characteristics of Functional Network Connectivity in Neurologically Asymptomatic Patients Undergoing Maintenance Hemodialysis: A Resting-State Functional MRI Study. J Magn Reson Imaging. Feb 2023;57(2):420-431. doi:10.1002/jmri.28317 [doi]
3. Margulies DS, Ghosh SS, Goulas A, et al. Situating the default-mode network along a principal gradient of macroscale cortical organization. Proc Natl Acad Sci U S A. Nov 1 2016;113(44):12574-12579. doi:10.1073/pnas.1608282113 [doi]
4. Hu Q, Li Y, Wu Y, Lin X, Zhao X. Brain network hierarchy reorganization in Alzheimer's disease: A resting-state functional magnetic resonance imaging study. Hum Brain Mapp. Aug 1 2022;43(11):3498-3507. doi:10.1002/hbm.25863 [doi]
5. Xia M, Liu J, Mechelli A, et al. Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes. Mol Psychiatry. Mar 2022;27(3):1384-1393. doi:10.1038/s41380-022-01519-5 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/567-04-003