531-02-017 / 531-02-017 ISMRM Abstract

Age-related Changes in Relaxation Do Not Drive Metabolite Aging Findings

Primary: Contrast Mechanisms - Relaxometry

Secondary: Contrast Mechanisms - Spectroscopy

531-02-017 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Aging Relaxometry MRS Metabolite Quantification

Accepted

Yulu Song¹, Christopher W Davies-Jenkins¹, Gizeaddis Simegn¹, Steve C Hui^2,3,4, Tao Gong⁵, Saipavitra Murali-Manohar¹, Vivek Yedavalli ¹, Helge Zoellner¹, Zahra Shams¹, Abdelrahman Gad¹, Dunja Simicic¹, Aaron Gudmundson⁶, Georg Oeltzschner¹, guangbin wang⁵, Eric C Porges^7,8, Richard AE Edden ^1,9

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America

²Developing Brain Institute, Children's National Hospital, Washington DC, United States of America

³Department of Radiology, George Washington University, Washington, United States of America

⁴Department of Pediatrics, George Washington University, Washington, United States of America

⁵Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250022, China

⁶The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, United States of America

⁷Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, United States of America

⁸Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, United States of America

⁹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States of America

Presenting Author: Richard AE Edden

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. (1) Deelchand, D. K.; McCarten, J. R.; Hemmy, L. S.; Auerbach, E. J.; Eberly, L. E.; Marjańska, M. Changes in the Intracellular Microenvironment in the Aging Human Brain. Neurobiol. Aging 2020, 95, 168–175. https://doi.org/10.1016/j.neurobiolaging.2020.07.017. [doi]

2. (2) Hupfeld, K. E.; Murali-Manohar, S.; Zöllner, H. J.; Song, Y.; Davies-Jenkins, C. W.; Gudmundson, A. T.; Simicic, D.; Lamesgin Simegn, G.; Carter, E. E.; Hui, S. C. N.; Yedavalli, V.; Oeltzschner, G.; Porges, E. C.; Edden, R. A. E. Metabolite T2 Relaxation Times Decrease across the Adult Lifespan in a Large Multi-Site Cohort. Magn. Reson. Med. 2024. https://doi.org/10.1002/mrm.30340. [doi]

3. (3) Jiru, F.; Skoch, A.; Wagnerova, D.; Dezortova, M.; Viskova, J.; Profant, O.; Syka, J.; Hajek, M. The Age Dependence of T2 Relaxation Times of N-Acetyl Aspartate, Creatine and Choline in the Human Brain at 3 and 4T. NMR Biomed. 2016, 29 (3), 284–292. https://doi.org/10.1002/nbm.3456. [doi]

4. (4) Kirov, I. I.; Fleysher, L.; Fleysher, R.; Patil, V.; Liu, S.; Gonen, O. Age Dependence of Regional Proton Metabolites T2 Relaxation Times in the Human Brain at 3 T. Magn. Reson. Med. 2008, 60 (4), 790–795. https://doi.org/10.1002/mrm.21715. [doi]

5. (5) Marjańska, M.; Emir, U. E.; Deelchand, D. K.; Terpstra, M. Faster Metabolite (1)H Transverse Relaxation in the Elder Human Brain. PloS One 2013, 8 (10), e77572. https://doi.org/10.1371/journal.pone.0077572. [doi]

6. (6) Gasparovic, C.; Song, T.; Devier, D.; Bockholt, H. J.; Caprihan, A.; Mullins, P. G.; Posse, S.; Jung, R. E.; Morrison, L. A. Use of Tissue Water as a Concentration Reference for Proton Spectroscopic Imaging. Magn. Reson. Med. 2006, 55 (6), 1219–1226. https://doi.org/10.1002/mrm.20901. [doi]

7. (7) Near, J.; Harris, A. D.; Juchem, C.; Kreis, R.; Marjańska, M.; Öz, G.; Slotboom, J.; Wilson, M.; Gasparovic, C. Preprocessing, Analysis and Quantification in Single-Voxel Magnetic Resonance Spectroscopy: Experts’ Consensus Recommendations. NMR Biomed. 2021, 34 (5), e4257. https://doi.org/10.1002/nbm.4257. [doi]

8. (8) Simegn, G. L.; Song, Y.; Murali-Manohar, S.; Zöllner, H. J.; Davies-Jenkins, C. W.; Simicic, D.; Hupfeld, K. E.; Gudmundson, A. T.; Muska, E.; Carter, E.; Hui, S. C. N.; Yedavalli, V.; Oeltzschner, G.; Dean, D. C.; Ceritoglu, C.; Ratnanather, J. T.; Porges, E.; Edden, R. A Water Relaxation Atlas for Age- and Region-Specific Metabolite Concentration Correction at 3 T. NMR Biomed. 2025, 38 (1), e5300. https://doi.org/10.1002/nbm.5300. [doi]

9. (9) Murali-Manohar, S.; Zöllner, H. J.; Hupfeld, K. E.; Song, Y.; Carter, E. E.; Yedavalli, V.; Hui, S. C. N.; Simicic, D.; Gudmundson, A. T.; Simegn, G. L.; Davies-Jenkins, C. W.; Oeltzschner, G.; Porges, E. C.; Edden, R. A. E. Age Dependency of Neurometabolite T1 Relaxation Times. Magn. Reson. Med. 2025, 94 (2), 508–520. https://doi.org/10.1002/mrm.30507. [doi]

10. (10) Gong, T.; Hui, S. C. N.; Zöllner, H. J.; Britton, M.; Song, Y.; Chen, Y.; Gudmundson, A. T.; Hupfeld, K. E.; Davies-Jenkins, C. W.; Murali-Manohar, S.; Porges, E. C.; Oeltzschner, G.; Chen, W.; Wang, G.; Edden, R. A. E. Neurometabolic Timecourse of Healthy Aging. NeuroImage 2022, 264, 119740. https://doi.org/10.1016/j.neuroimage.2022.119740. [doi]

11. (11) Oeltzschner, G.; Zöllner, H. J.; Hui, S. C. N.; Mikkelsen, M.; Saleh, M. G.; Tapper, S.; Edden, R. A. E. Osprey: Open-Source Processing, Reconstruction & Estimation of Magnetic Resonance Spectroscopy Data. J. Neurosci. Methods 2020, 343, 108827. https://doi.org/10.1016/j.jneumeth.2020.108827. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-02-017