Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
405-02-004 / 271-01-031 ISMRM Abstract

Paramagnetic Changes in Multiple Sclerosis: Imaging-Pathology Correlations

Primary: Neuro - Multiple Sclerosis
Secondary: Preclinical Animal & in vitro MR - Biomarkers
405-02-004 · What's New in Multiple Sclerosis? · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom West
271-01-031 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters
Keywords: Validation Multiple Sclerosis Ex vivo MRI Paramagnetic rim lesion Histopathology
Accepted
Kedar R Mahajan1,2, Kathryn Ryan2, Kunio Nakamura3, Ken Sakaie 4, Mark Lowe4, Bruce D Trapp2, Stephen E Jones4, Emmanuel Obusez4
1Mellen Center for MS Treatment and Research, Cleveland Clinic, Cleveland, United States of America
2Department of Neurosciences, Cleveland Clinic Research, Cleveland, United States of America
3Biomedical Engineering, Cleveland Clinic Research, Cleveland, United States of America
4Diagnostic Radiology, Cleveland Clinic, Cleveland, United States of America
Presenting Author: Ken Sakaie

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. 1. Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS. Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo. JAMA Neurol. 2019;76(12):1474-83. doi: 10.1001/jamaneurol.2019.2399. PubMed PMID: 31403674; PMCID: PMC6692692. [doi] [pmid]
2. 2. Reeves JA, Mohebbi M, Wicks T, Salman F, Bartnik A, Jakimovski D, Bergsland N, Schweser F, Weinstock-Guttman B, Dwyer MG, Zivadinov R. Paramagnetic rim lesions predict greater long-term relapse rates and clinical progression over 10 years. Mult Scler. 2024;30(4-5):535-45. Epub 20240217. doi: 10.1177/13524585241229956. PubMed PMID: 38366920; PMCID: PMC11009059. [doi] [pmid]
3. 3. Dal-Bianco A, Grabner G, Kronnerwetter C, Weber M, Hoftberger R, Berger T, Auff E, Leutmezer F, Trattnig S, Lassmann H, Bagnato F, Hametner S. Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging. Acta Neuropathol. 2017;133(1):25-42. Epub 20161027. doi: 10.1007/s00401-016-1636-z. PubMed PMID: 27796537; PMCID: PMC5209400. [doi] [pmid]
4. 4. Dutta R, Mahajan KR, Nakamura K, Ontaneda D, Chen J, Volsko C, Dudman J, Christie E, Dunham J, Fox RJ, Trapp BD. Comprehensive Autopsy Program for Individuals with Multiple Sclerosis. J Vis Exp. 2019(149). Epub 20190719. doi: 10.3791/59511. PubMed PMID: 31380830. [doi] [pmid]
5. 5. Kim S, Sakaie K, Blumcke I, Jones S, Lowe MJ. Whole-brain, ultra-high spatial resolution ex vivo MRI with off-the-shelf components. Magn Reson Imaging. 2021;76:39-48. doi: 10.1016/j.mri.2020.11.002. PubMed PMID: 33197550. [doi] [pmid]
6. 6. Eckstein K, Bachrata B, Hangel G, Widhalm G, Enzinger C, Barth M, Trattnig S, Robinson SD. Improved susceptibility weighted imaging at ultra-high field using bipolar multi-echo acquisition and optimized image processing: CLEAR-SWI. Neuroimage. 2021;237:118175. Epub 20210515. doi: 10.1016/j.neuroimage.2021.118175. PubMed PMID: 34000407; PMCID: PMC7612087. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/405-02-004