Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-03-008 ISMRM Abstract

Detection of Macromolecular Changes in Brain Tumor Using 1H FID MRSI at 7T

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Tumors
469-03-008 · Software and Analysis for MR Spectroscopy and Chemical Shift Imaging · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row J
Keywords: Biomarkers Brain tumor Macromolecules Tumor Metabolism 1H-MRSI
Accepted
Mahrshi Jani 1, Andrew Wright1, Yeison Rodriguez1, Kimberly L Chan1, Anke Henning1
1University of Texas Southwestern Medical Center, Dallas, United States of America
Presenting Author: Mahrshi Jani

Synopsis

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References

1. Wright AM, Murali-Manohar S, Henning A. Quantitative T1-relaxation corrected metabolite mapping of 12 metabolites in the human brain at 9.4 T. Neuroimage. 2022 Nov;263:119574. doi: 10.1016/j.neuroimage.2022.119574. Epub 2022 Sep 1. PMID: 36058442. [doi] [pmid]
2. Chan KL, Henning A. MultiNet CAIPIRINHA: accelerated H MRSI with 1-step neural network reconstruction based on augmented MRSI training data. Proceedings of the 30th annual scientific meeting of ISMRM, May 7th – 12th 2022,London, UK.
3. Ziegs, T, Wright, AM, Henning, A. Test–retest reproducibility of human brain multi-slice 1H FID-MRSI data at 9.4T after optimization of lipid regularization, macromolecular model, and spline baseline stiffness. Magn Reson Med. 2023; 89: 11-28. doi:10.1002/mrm.29423. [doi]
4. Wright AM, MuraliManohar S, Borbath T, Avdievich NI, Henning A. Relaxation-corrected macromolecular model enables determination of 1H longitudinal T1-relaxation times and concentrations of human brain metabolites at 9.4T. Magn Reson Med. 2021; 87: 33-49. https://doi.org/10.1002/mrm.28958. [doi]
5. U.Baid, et al., "The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification", arXiv:2107.02314, 2021.
6. B. H. Menze, A. Jakab, S. Bauer, J. Kalpathy-Cramer, K. Farahani, J. Kirby, et al. "The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS)", IEEE Transactions on Medical Imaging 34(10), 1993-2024 (2015) DOI: 10.1109/TMI.2014.2377694 [doi]
7. S. Bakas, H. Akbari, A. Sotiras, M. Bilello, M. Rozycki, J.S. Kirby, et al., "Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features", Nature Scientific Data, 4:170117 (2017) DOI: 10.1038/sdata.2017.117. [doi]
8. Boskovic P, Wilke N, Man KH, Lichter P, Francois L, Radlwimmer B. Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression. Neuro Oncol. 2024 Feb 2;26(2):251-265. doi: 10.1093/neuonc/noad190. PMID: 37769206; PMCID: PMC10836774. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/469-03-008