369-03-004 ISMRM Abstract

Microstructural Alterations of Normal Appearing White Matter Assessed by Quantitative Multiparametric Mapping

Primary: Neuro - Stroke and Cerebrovascular Disorders

Secondary: Brain Function and fMRI

369-03-004 · Multiparametric MRI in Stroke · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row J

Keywords: Cerebral small vessel disease Normal Appearing White Matter 3.0 T Region-of-interest analysis Multiparametric quantitative MRI

Accepted

Huma Fatima Ali¹, Markus E Klammer¹, Tobias Leutritz², Ralf Mekle^3,4, Andrea Dell'Orco⁵, Christian Stehning⁶, Stefan Hetzer^4,7, Joachim E Weber^1,8,9, Michael Ahmadi^8,9, Sophie K Piper^10,11, Katharina Schönrath⁹, Ira Rohrpasser-Napierkowski⁹, Nikolaus Weiskopf^12,13,14,15, Jeanette Schulz-Menger¹⁶, Anja Hennemuth^{4,17,18,19,20,21,22}, Matthias Endres^3,8,23,24, Kersten Villringer ²⁵

¹Center for Stroke Research Berlin, Charité-Universitätsmedizin, Berlin, Germany

²Department of Neurophysics, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

³Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany

⁴Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

⁵Institute for Neuroradiology, Charité – Universitätsmedizin Berlin, Berlin, Germany

⁶Philips Clinical Science DACH, Hamburg, Germany

⁷Charité – Universitätsmedizin Berlin, Berlin, Germany

⁸Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology with Experimental Neurology, Berlin, Germany

⁹Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Germany

¹⁰Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany

¹¹Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany

¹²Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth System Sciences, Leipzig University, Leipzig, Germany

¹³Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

¹⁴Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

¹⁵Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

¹⁶ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

¹⁷Institute of Computer-assisted Cardiovascular Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

¹⁸Fraunhofer MEVIS, Bremen, Berlin, Germany

¹⁹Hinrich Rahlfs, Berlin, Germany

²⁰DZHK (German Centre for Cardiovascular Research), Berlin, Germany

²¹Partner Site Berlin, DZHK (German Centre for Cardiovascular Research), Berlin, Germany

²²Institute of Computer-assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany

²³German Center for Mental Health, Berlin, Germany

²⁴Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Neurocure Cluster of Excellence, Berlin, Germany

²⁵Center for Stroke Research Berlin, Charité – Universitätsmedizin, Berlin, Germany

Presenting Author: Kersten Villringer

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References

1. Gons RA, de Laat KF, van Norden AG, et al. Hypertension and cerebral diffusion tensor imaging in small vessel disease. Stroke. 2010 Dec;41(12):2801-6. doi: 10.1161/STROKEAHA.110.597237. [doi]

2. Draganski B, Ashburner J, Hutton C, et al. Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ). Neuroimage. 2011 Apr 15;55(4):1423-34. doi: 10.1016/j.neuroimage.2011.01.052 [doi]

3. Weiskopf N, Edwards LJ, Helms G, et al. Quantitative magnetic resonance imaging of brain anatomy and in vivo histology. Nature Reviews Physics 2021, 570-588. doi 10.1038/s42254-021-00326-1 [doi]

4. Weber JE, Ahmadi M, Boldt LH, et al. Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients. BMJ Open. 2023 Oct 31;13(10): e076415. doi: 10.1136/bmjopen-2023-076415 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-03-004