460-06-013 Registered Abstract

Magnifying (G)Lymphatics: Insights into Sexual Dimorphism in Brain Clearance Mechanisms.

Primary: Neuro - Aging

Secondary: Neuro - Neurofluids

460-06-013 · Imaging the Brain’s Microenvironment: From Glymphatics to Cognition · Tuesday, 12 May, 4:55 PM–5:50 PM · Digital Posters Row A

Keywords: Aging Structure function coupling Glymphatic system (GS) Sex differences Neurofluid dynamics

Accepted

J. Kent Werner^1,2, Nastaren Abad³, Luca Marinelli³, Barbara B Bendlin⁴, Maria Greufe⁴, Theresa Kang⁴, Sandy Harding⁴, J. Kevin DeMarco, Steven R Kecskemeti⁴, Melanie Boly⁴, Isabelle Heukensfeldt Jansen³, Thomas K Foo³, Chitresh Bhushan³, Muhan Shao³, Angeliki Pollatou¹, JoAnn E Manson⁵, Sara Tirner, Andrew L Alexander ^4,6

¹Uniformed Services University of the Health Sciences, Bethesda, United States of America

²Walter Reed National Military Medical Center, Bethesda, United States of America

³GE HealthCare Technology and Innovation Center, Niskayuna, United States of America

⁴University of Wisconsin - Madison, Madison, United States of America

⁵Brigham and Women's Hospital and Harvard Medical School, Boston, United States of America

⁶Department of Medical Physics, Department of Psychiatry, Waisman Center, University of Wisconsin Madison, Madison, United States of America

Presenting Author: Andrew L Alexander

Synopsis

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References

1. Castro-Aldrete, L., et al., Sex and gender considerations in Alzheimer's disease: The Women's Brain Project contribution. Front Aging Neurosci, 2023. 15: p. 1105620.

2. Nebel, R.A., et al., Understanding the impact of sex and gender in Alzheimer's disease: A call to action. Alzheimers Dement, 2018. 14(9): p. 1171-1183.

3. Toro, C.A., et al., Sex differences in Alzheimer's disease: Understanding the molecular impact. Brain Res, 2019. 1719: p. 194-207.

4. Ardekani, B.A., A. Convit, and A.H. Bachman, Analysis of the MIRIAD Data Shows Sex Differences in Hippocampal Atrophy Progression. J Alzheimers Dis, 2016. 50(3): p. 847-57.

5. Andica, C., et al., Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome. Neurobiol Dis, 2023. 177: p. 105990.

6. Dai, W., et al., A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice. Nat Commun, 2022. 13(1): p. 4825.

7. Han, F., et al., Sex-specific age-related changes in glymphatic function assessed by resting-state functional magnetic resonance imaging. bioRxiv, 2023.

8. Foo, T.K.F., et al., Highly efficient head-only magnetic field insert gradient coil for achieving simultaneous high gradient amplitude and slew rate at 3.0T (MAGNUS) for brain microstructure imaging. Magnetic Resonance in Medicine, 2020. 83(6): p. 2356-2369.

9. Heukensfeldt Jansen, I., Abad, N., Ajala, A., Bhushan, C., Werner, J. K., DeMarco, J. K., ... & Marinelli, L. (2025). Simultaneous coherent–incoherent motion imaging in brain parenchyma. Interface Focus, 15(1), 20240041.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-06-013