366-02-011 ISMRM Abstract

Aberrant Functional Connectivity Gradients Reveal Cortical Reorganization and Cognitive Correlates in Thalassemia

Primary: Brain Function and fMRI - Functional Connectivity

Secondary: Neuro - Gray Matter

366-02-011 · Brain-Body Axis · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row G

Keywords: Functional Connectivity Rs-fMRI Cognitive Function Thalassemia Gradient Mapping

Accepted

Mingrui Yang^1,2, Peng Peng ^2,3, Huang Yugui², Kong Rong², Chunxia Zhu², Cheng Tang^2,3, Guowei Chen², Hui Zhang⁴

¹Binzhou Medical University Hospital, Binzhou, China

²The First Affiliated Hospital of Guangxi Medical University,, Nanning, China

³NHC Key Laboratory of Thalassemia Medicine., Nanning, China

⁴MR Research Collaboration Team, Shanghai, China

Presenting Author: Peng Peng

Synopsis

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References

1. Kattamis, A., J.L. Kwiatkowski, and Y. Aydinok, Thalassaemia. Lancet, 2022. 399(10343): p. 2310-2324.

2. Manara, R., et al., Brain perfusion changes in beta-thalassemia. Orphanet J Rare Dis, 2024. 19(1): p. 212.

3. Bu, M., et al., Brain iron content and cognitive function in patients with beta-thalassemia. Ther Adv Hematol, 2023. 14: p. 20406207231167050.

4. Vachha, B.A., et al., Resting-State Functional MRI: Current State, Controversies, Limitations, and Future Directions-AJR Expert Panel Narrative Review. AJR Am J Roentgenol, 2025. 225(3): p. e2432163.

5. Yao, L., et al., Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline. Front Psychiatry, 2024. 15: p. 1360623.

6. Power, L.C., et al., Reversibility of Cognitive Deficits and Functional Connectivity With Transfusion in Children With Sickle Cell Disease. Neurology, 2024. 102(10): p. e209429.

7. Wu, G., et al., Sex Differences in Functional Gradients and Dynamic Functional Connectivity in Preschool-Aged Children With ASD. CNS Neurosci Ther, 2025. 31(8): p. e70562.

8. Huang, R., et al., Aberrant static and dynamic functional network connectivity in patients with noise-induced hearing loss. Quant Imaging Med Surg, 2025. 15(5): p. 3891-3910.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-02-011