Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
431-01-003 / 431-01-003 ISMRM Abstract

Perfusion-Metabolic Decoupling as an Imaging Marker for Radiation Necrosis After Stereotactic Radiosurgery

Primary: Neuro - Tumors
Secondary: Analysis Methods - Classification and Prediction
431-01-003 · From Microstructure to Metabolism: Next-Generation MRI for Brain Tumors · Tuesday, 12 May, 8:20 AM–9:56 AM · Roof Terrace
431-01-003 · From Microstructure to Metabolism: Next-Generation MRI for Brain Tumors · Tuesday, 12 May, 8:20 AM–9:56 AM · Roof Terrace
Keywords: Analysis/Processing CEST & MT DSC & DCE Perfusion Translational Studies Radiosurgery
Accepted
Dylan Young 1,2, Wilfred W Lam2, Rachel W Chan2, Dafna Sussman3,4, Pejman J Maralani5, Arjun Sahgal6,7,8, Hany Soliman6,7, Greg Stanisz2,4,9
1Department of Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, Toronto, Canada
2Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
3Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, Toronto, Canada
4Department of Medical Biophysics, University of Toronto, Toronto, Canada
5Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
6Department of Radiation Oncology, University of Toronto, Toronto, Canada
7Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada
8Sunnybrook Health Sciences Centre, Toronto, Canada
9Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland
Presenting Author: Dylan Young

Synopsis

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References

1. Dobeson CB, Birkbeck M, Bhatnagar P, et al. Perfusion MRI in the evaluation of brain metastases: current practice review and rationale for study of baseline MR perfusion imaging prior to stereotactic radiosurgery (STARBEAM-X). Br J Radiol. 2023;96(1152):20220462. doi:10.1259/bjr.20220462 [doi]
2. Vellayappan B, Lim-Fat MJ, Kotecha R, et al. A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations. Int J Radiat Oncol Biol Phys. 2024;118(1):14-28. doi:10.1016/j.ijrobp.2023.07.015 [doi]
3. Rahmathulla G, Marko NF, Weil RJ. Cerebral radiation necrosis: A review of the pathobiology, diagnosis and management considerations. Accessed October 30, 2025. https://www.jocn-journal.com/article/S0967-5868(12)00575-9/fulltext
4. Mehrabian H, Desmond KL, Soliman H, Sahgal A, Stanisz GJ. Differentiation between Radiation Necrosis and Tumor Progression Using Chemical Exchange Saturation Transfer. Clinical Cancer Research. 2017;23(14):3667-3675. doi:10.1158/1078-0432.CCR-16-2265 [doi]
5. Mehrabian H, Chan RW, Sahgal A, et al. Chemical Exchange Saturation Transfer MRI for Differentiating Radiation Necrosis From Tumor Progression in Brain Metastasis—Application in a Clinical Setting. Journal of Magnetic Resonance Imaging. 2023;57(6):1713-1725. doi:10.1002/jmri.28440 [doi]
6. Chan RW, Lam WW, Chen H, et al. Is pulsed saturation transfer sufficient for differentiating radiation necrosis from tumor progression in brain metastases? Neurooncol Adv. 2024;6(1):vdae132. doi:10.1093/noajnl/vdae132 [doi]
7. Young D, Lam WW, Chan RW, et al. Saturation Transfer Imaging Radiomics using Machine Learning Improves Differentiation of Tumour Progression from Radiation Necrosis in Brain Metastases. Neuro Oncol Adv. Published online September 13, 2025:vdaf206. doi:10.1093/noajnl/vdaf206 [doi]
8. Jahng GH, Li KL, Ostergaard L, Calamante F. Perfusion Magnetic Resonance Imaging: A Comprehensive Update on Principles and Techniques. Korean J Radiol. 2014;15(5):554-577. doi:10.3348/kjr.2014.15.5.554 [doi]
9. Kwee RM, Kwee TC. Dynamic susceptibility MR perfusion in diagnosing recurrent brain metastases after radiotherapy: A systematic review and meta‐analysis. J Magn Reson Imaging. 2020;51(2):524-534. doi:10.1002/jmri.26812 [doi]
10. Mitsuya K, Nakasu Y, Horiguchi S, et al. Perfusion weighted magnetic resonance imaging to distinguish the recurrence of metastatic brain tumors from radiation necrosis after stereotactic radiosurgery. Journal of Neuro-Oncology. 2010;99(1):81-88. doi:10.1007/s11060-009-0106-z [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/431-01-003