Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-05-005 ISMRM Abstract

Feasibility of MR Elastography in Head & Neck Cancer

Primary: Contrast Mechanisms - Elastography
Secondary: Acquisition & Reconstruction - Quantitative Imaging: head and neck
361-05-005 · Quantitative Imaging: Head and Neck I · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row B
Keywords: Cancer Elastography Magnetic Resonance Elastography Head and Neck HNSCC
Accepted
Anne-Sophie van Schelt 1, Sanjena Mithra2,3, Karen Welsh4, Tony Ng2,3, Alan Wright5, Matthew T Cherukara1,6, Karin Shmueli6, Steve Connor4, Martin Forster7, Ralph Sinkus8,9
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
2School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
3Cancer Institute, University College London, London, United Kingdom
4Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
5Medical Physics and Clinical Engineering, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
6Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom
7Department of Oncology, University College London, London, United Kingdom
8Department of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
9LVTS, Inserm U1148, University Paris Diderot, Paris, France
Presenting Author: Anne-Sophie van Schelt

Synopsis

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References

1. Bello, I. O. et al. Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer. Oral Oncol 47, 33-38 (2011). https://doi.org/10.1016/j.oraloncology.2010.10.013 [doi]
2. Ding, L. et al. α-Smooth muscle actin-positive myofibroblasts, in association with epithelial-mesenchymal transition and lymphogenesis, is a critical prognostic parameter in patients with oral tongue squamous cell carcinoma. J Oral Pathol Med 43, 335-343 (2014). https://doi.org/10.1111/jop.12143 [doi]
3. Dourado, M. R., Guerra, E. N. S., Salo, T., Lambert, D. W. & Coletta, R. D. Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: A systematic review and meta-analysis. J Oral Pathol Med 47, 443-453 (2018). https://doi.org/10.1111/jop.12623 [doi]
4. Moloney, E. C., Brunner, M., Alexander, A. J. & Clark, J. Quantifying fibrosis in head and neck cancer treatment: An overview. Head & Neck 37, 1225-1231 (2015). https://doi.org/https://doi.org/10.1002/hed.23722 [doi]
5. Yeung, D. K. W. et al. MR elastography of the head and neck: Driver design and initial results. Magnetic Resonance Imaging 31, 624-629 (2013). https://doi.org/https://doi.org/10.1016/j.mri.2012.09.008 [doi]
6. Atamaniuk, V. et al. High-frequency shear wave MR elastography of parotid glands: custom driver design and preliminary results. Scientific Reports 14, 24496 (2024). https://doi.org/10.1038/s41598-024-75806-2 [doi]
7. Chen, J. et al. Assessment of metastatic lymph nodes in head and neck squamous cell carcinomas using simultaneous 18F-FDG-PET and MRI. Scientific Reports 10, 20764 (2020). https://doi.org/10.1038/s41598-020-77740-5 [doi]
8. Sinkus, R. et al. Rheological determinants for simultaneous staging of hepatic fibrosis and inflammation in patients with chronic liver disease. NMR Biomed 31, e3956 (2018). https://doi.org/10.1002/nbm.3956 [doi]
9. Guo, Z. et al. The role of the tumor microenvironment in HNSCC resistance and targeted therapy. Frontiers in Immunology Volume 16 - 2025 (2025). https://doi.org/10.3389/fimmu.2025.1554835 [doi]
10. Renslo, B. et al. Quantification of Radiation-Induced Fibrosis in Head and Neck Cancer Patients Using Shear Wave Elastography. Cureus 16, e71159 (2024). https://doi.org/10.7759/cureus.71159 [doi]
11. Matte, B. F. et al. Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma. J Cell Sci 132 (2019). https://doi.org/10.1242/jcs.224360 [doi]

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http://echo.ismrm.org/p/ISMRM2026/361-05-005