Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
660-03-013 ISMRM Abstract

Characterizing human brain glycogen concentration in Lafora Disease by 2-step Lorentzian fitting of 7T GlycoNOE measurement

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Pediatrics - Neuro
660-03-013 · Advances in Chemical Exchange MRI: CEST, APT, and NOE I · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row A
Keywords: CEST / APT / NOE 7T Glycogen Metabolic imaging Paediatric neuroimaging
Accepted
Yuxin Lan1, Mayank Verma2,3, Berge Minassian2,3, Nirbhay Yadav4,5, Anke Henning 1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Neurology, University of Texas Southwestern Medical Center, Dallas, United States of America
3Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, United States of America
4F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, United States of America
5Department of Radiology, Johns Hopkins University, Baltimore, United States of America
Presenting Author: Anke Henning

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References

1. Pondrelli, F., et al., Natural history of Lafora disease: a prognostic systematic review and individual participant data meta-analysis. Orphanet Journal of Rare Diseases, 2021. 16(1): p. 362. doi: 10.1186/s13023-021-01989-w [doi]
2. Sullivan, M.A., et al. Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan. International Journal of Molecular Sciences, 2017. 18, doi: 10.3390/ijms18081743. [doi]
3. Raththagala, M., et al., Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease. Molecular Cell, 2015. 57(2): p. 261-272. doi: 10.1016/j.molcel.2014.11.020 [doi]
4. Gentry, M.S., et al., Lafora disease offers a unique window into neuronal glycogen metabolism. Journal of Biological Chemistry, 2018. 293(19): p. 7117-7125. doi: 10.1074/jbc.R117.803064 [doi]
5. Ahonen, S., et al., Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease. Brain, 2021. 144(10): p. 2985-2993. doi: 10.1093/brain/awab194 [doi]
6. Donohue, K.J., et al., Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model. Neurotherapeutics, 2023. 20(6): p. 1808-1819. doi: 10.1007/s13311-023-01434-9 [doi]
7. Xu, X., et al., MRI of GlycoNOE in the human liver using GraspNOE-Dixon. Magnetic Resonance in Medicine, 2025. 93(2): p. 507-518. doi: 10.1002/mrm.30270 [doi]
8. Bie, C., et al., In vivo imaging of glycogen in human muscle. Nature Communications, 2024. 15(1): p. 10826. doi: 10.1038/s41467-024-55132-x [doi]
9. Zhou, Y., et al., Magnetic resonance imaging of glycogen using its magnetic coupling with water. Proceedings of the National Academy of Sciences, 2020. 117(6): p. 3144-3149. doi: 10.1073/pnas.1909921117 [doi]
10. Keupp, J., et al. Parallel RF Transmission based MRI Technique for Highly Sensitive Detection of Amide Proton Transfer in the Human Brain at 3T. in The International Society for Magnetic Resonance in Medicine. 2011. Montréal, QC, Canada.
11. Kim, M., et al., Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med, 2009. 61(6): p. 1441-50. doi: 10.1002/mrm.21873 [doi]
12. Zaiß, M., B. Schmitt, and P. Bachert, Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. Journal of Magnetic Resonance, 2011. 211(2): p. 149-155. doi: 10.1016/j.jmr.2011.05.001 [doi]
13. Kong, J., et al., Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep. The Journal of Neuroscience, 2002. 22(13): p. 5581. doi: 10.1523/JNEUROSCI.22-13-05581.2002 [doi]

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http://echo.ismrm.org/p/ISMRM2026/660-03-013