Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-007 ISMRM Abstract

Morphological Changes of subcortical regions in the developing brains of a transgenic monkey model of Huntington’s Disease

Primary: Neuro - Other Neurodegeneration
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
664-02-007 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: Subcortical structure Huntingtons disease Diffusion Tensor Imaging (DTI) Volume measurement Macaque brain
Accepted
Rong Wang 1, Qiliang Du1, Pengzhan Xu1, Binglei Huang1, Yuanshun Chen1, Xiaofei Chang1, Xiaodong Zhang1
1State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China
Presenting Author: Rong Wang

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References

1. Glikmann-Johnston Y, Delagneau G, Barta T, Stout JC, Razi A. Neural Mechanisms of Object Location Memory in Huntington's Disease. Mov Disord. 2025 Aug;40(8):1692-1703. doi: 10.1002/mds.30232. Epub 2025 May 28. PMID: 40432572; PMCID: PMC12371679. [doi] [pmid]
2. Handsaker RE, Kashin S, Reed NM, Tan S, Lee WS, McDonald TM, Morris K, Kamitaki N, Mullally CD, Morakabati NR, Goldman M, Lind G, Kohli R, Lawton E, Hogan M, Ichihara K, Berretta S, McCarroll SA. Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease. Cell. 2025 Feb 6;188(3):623-639.e19. doi: 10.1016/j.cell.2024.11.038. Epub 2025 Jan 16. PMID: 39824182; PMCID: PMC11822645. [doi] [pmid]
3. Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW. Towards a transgenic model of Huntington's disease in a non-human primate. Nature. 2008 Jun 12;453(7197):921-4. doi: 10.1038/nature06975. Epub 2008 May 18. PMID: 18488016; PMCID: PMC2652570. [doi] [pmid]
4. Farag M, Knights H, Scahill RI, McColgan P, Estevez-Fraga C. Neuroimaging Techniques in Huntington's Disease: A Critical Review. Mov Disord Clin Pract. 2025 May;12(5):561-576. doi: 10.1002/mdc3.70010. Epub 2025 Feb 20. PMID: 39976324; PMCID: PMC12070181. [doi] [pmid]
5. Lila E, Hunt D, Child DD, Latimer C, Le B, Davis M, Jayadev S, Bird TD, Shojaie A, Mac Donald CL. Asymmetric brain atrophy in Huntington's disease: A postmortem MRI study. J Huntingtons Dis. 2025 May;14(2):132-139. doi: 10.1177/18796397251333334. Epub 2025 Apr 13. PMID: 40221975; PMCID: PMC12419748. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/664-02-007