Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-02-007 ISMRM Abstract

Time-Dependent Diffusion MRI for Predicting Response to Induction Chemotherapy in Nasopharyngeal Carcinoma

Primary: Diffusion - Microstructure
Secondary: Body - Whole Body Imaging
363-02-007 · All About Diffusion · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row D
Keywords: Nasopharyngeal carcinoma Time-dependent microstructure diffusion MRI Chemotherapy Response
Accepted
Huanhuan Ren 1, Diwei Shi2, Qian Xu3, Yao Huang4, Yulin Wang3, Daihong Liu5, Hua Guo6,7, Junzhong Xu8,9,10,11, Junhao Huang12, Xinying Ren13, Lisha Nie14, Jiuquan Zhang15
1Chongqing University Cancer Hospital, Chongqing, China
2Tsinghua University, Beijing, China
3School of Medicine, School of Medicine, Chongqing University, China
4School of Medicine, Chongqing University, China
5Department of Radiology Chongqing University Cancer Hospital, Chongqing, chongqing, China
6Center for Biomedical Imaging Research, Tsinghua University, Beijing, China
7School of Biomedical Engineering, Tsinghua University, Beijing, China
8Department of Biomedical Engineering, Vanderbilt University, Nashville, United States of America
9Department of Physics and Astronomy, Vanderbilt University, Nashville, United States of America
10Institute of Imaging Science;, Vanderbilt University Medical Center, Nashville, United States of America
11Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, United States of America
12Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, ChongQing, China
13Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China
14GE Healthcare, MR Research China, Beijing, China
15Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, ChongQing, China
Presenting Author: Huanhuan Ren

Synopsis

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References

1. Tang LL, Chen YP, Chen CB, Chen MY, Chen NY, Chen XZ, et al. The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma. Cancer Commun (Lond) 2021;41:1195-1227
2. Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, et al. Final Overall Survival Analysis of Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma: A Multicenter, Randomized Phase III Trial. J Clin Oncol 2022;40:2420-2425
3. Wu D, Jiang K, Li H, Zhang Z, Ba R, Zhang Y, et al. Time-Dependent Diffusion MRI for Quantitative Microstructural Mapping of Prostate Cancer. Radiology 2022;303:578-587
4. Zhang H, Liu K, Ba R, Zhang Z, Zhang Y, Chen Y, et al. Histological and molecular classifications of pediatric glioma with time-dependent diffusion MRI-based microstructural mapping. Neuro Oncol 2023;25:1146-1156
5. Almangush A, Ruuskanen M, Hagström J, Kosma VM, Nieminen P, Mäkitie AA, et al. Prognostic Significance of Tumor-associated Stroma in Nasopharyngeal Carcinoma: A Multicenter Study. Am J Surg Pathol 2024;48:54-58
6. Pflüger I, Rastogi A, Casagranda S, Papageorgakis C, Behnisch R, Liebig P, et al. Amide proton transfer weighted MRI measurements yield consistent and repeatable results in patients with gliomas: a prospective test-retest study. Eur Radiol 2025;35:3367-3379
7. Miroshnychenko D, Miti T, Kumar P, Miller A, Laurie M, Giraldo N, et al. Stroma-Mediated Breast Cancer Cell Proliferation Indirectly Drives Chemoresistance by Accelerating Tumor Recovery between Chemotherapy Cycles. Cancer Res 2023;83:3681-3692
8. Lou E, Clemente V, Grube M, Svedbom A, Nelson AC, Blome F, et al. Tumor-Stroma Proportion to Predict Chemoresistance in Patients With Ovarian Cancer. JAMA Netw Open 2024;7:e240407
9. Wang X, Ba R, Huang Y, Cao Y, Chen H, Xu H, et al. Time-Dependent Diffusion MRI Helps Predict Molecular Subtypes and Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer. Radiology 2024;313:e240288
10. Yao J, Wang Y, Lin Y, Yang Y, Wan J, Gong X, et al. The Role of Pretreatment (18)F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma. Drug Des Devel Ther 2021;15:4157-4166

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-02-007