666-01-003 ISMRM Abstract

Electron irradiation-induced radicals as stable endogenous agents for sodium [1-13C]pyruvate Dynamic Nuclear Polarisation

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Contrast Mechanisms - Electron Paramagnetic Resonance

666-01-003 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: Electron Paramagnetic Resonance Hyperpolarized MR (Non-Gas) 1-13C Pyruvate Dynamic Nuclear Polarisation Radicals

Accepted

Zoe Richardson ¹, William K Myers², Iain Tullis³, Nichlas Vous Christensen⁴, Duy Anh Dang⁴, Esben S Hansen⁴, Zhuang Liu⁵, Lotte Bonde Bertelsen⁴, Kristoffer Petersson³, Christoffer Laustsen⁴, Damian Tyler^5,6, Jack J Miller⁴, Catriona Rooney⁶

¹University College London, London, United Kingdom

²Centre for Advanced ESR, Inorganic Chemistry Laboratory, University of Oxford, Oxford, United Kingdom

³Department of Oncology, University of Oxford, Oxford, United Kingdom

⁴MR Research Centre, Aarhus University, Aarhus, Denmark

⁵Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom

⁶Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Presenting Author: Zoe Richardson

Synopsis

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References

1. Larson PEZ, Hu S, Merritt ME, et al. Current methods for hyperpolarized [1-¹³C]pyruvate MRI. Magn Reson Med. 2024;91(6):2204-2228. PMID: 37731660 [pmid]

2. Ardenkjær-Larsen JH, Laursen I, Leunbach I, et al. EPR and DNP properties of novel agents for oximetric imaging. J Magn Reson. 1998;133(1):1-12. PMID: 9654463 [pmid]

3. Eichhorn TR, Takado Y, Salameh N, et al. Hyperpolarization without persistent radicals for imaging. Proc Natl Acad Sci U S A. 2013;110(45):18064-18069. doi:10.1073/pnas.1314928110 [doi]

4. Capozzi A, Cheng T, Boero G, et al. Efficient hyperpolarization of U-¹³C-glucose using narrow-line UV-generated labile free radicals. Angew Chem Int Ed Engl. 2019;58:1334-1339. PMID: 30515929 [pmid]

5. Rooney CHE, Smith JS, Patel N, et al. 6 MeV electron-irradiated ¹³C-alanine for DNP. In: Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM); 2024.

6. Rooney CHE, Lau JYC, Hansen ESS, et al. Stable electron-irradiated [1-¹³C]alanine radicals for clinically viable metabolic imaging with dynamic nuclear polarization. arXiv. Published online 2025. doi:10.48550/arXiv.2504.16621 [doi]

7. Ferrari A, Peters J, Anikeeva M, et al. Performance and reproducibility of 13C and 15N hyperpolarization using a cryogen-free DNP polarizer. Scientific Reports. 2022;12(1). doi:10.1038/s41598-022-15380-7 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-003