Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-03-010 ISMRM Abstract

Multimodal MRI Reveals Melatonin-Induced Oligodendrogenesis Through AKT/GSK-3β/β-Catenin Signaling in PWMI rats

Primary: Neuro - White Matter
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
301-03-010 · Neuroimaging and Spectroscopy in Experimental Models · Monday, 11 May, 1:50 PM–3:40 PM · Hall 1A
Keywords: Multi-modal MRI Melatonin Perinatal white matter injury Oligodendrocyte precursor cells Neonatal rats
Accepted
Xiaoli Wang1,2, Xiaozu Zhang1, Haimo Zhang1,3, Youcheng Qin1, Zhigang Yang1, Xiaotian Gao1, Yijing Wang1, Peng Wu 4, Xizhen Wang2
1School of Medical Imaging, Shandong Second Medical University, Weifang, China
2Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
3Department of Medical Laboratory Animal Center, Shandong Second Medical University, Weifang, China
4Clinical & Technical Support, Philips Healthcare, Guangzhou, China
Presenting Author: Peng Wu

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References

1. Rees P, Callan C, Chadda KR, et al. Preterm brain injury and neurodevelopmental outcomes: a meta-analysis[J]. Pediatrics. 2022;150(6):e2022057442.PMID:36330752. [pmid]
2. Vaes JEG, Brandt MJV, Wanders N, et al. The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: Potential treatments for encephalopathy of prematurity[J]. Glia. 2021;69(6):1311-1340.PMID:33595855. [pmid]
3. Akkermann R, Beyer F, Küry P. Heterogeneous populations of neural stem cells contribute to myelin repair[J]. Neural Regen Res. 2017;12(4):509-517.PMID:28553319. [pmid]
4. Wang S, Chen Z, Liang Z,et al. Bright night sleeping environment induces diabetes and impaired glucose tolerance in non-human primates[J]. Front Endocrinol (Lausanne). 2025;16:1454592.PMID:40013312. [pmid]
5. Wu WJ, Jiang CJ, Zhang ZY, et al. Diffusion-weighted magnetic resonance imaging reflects activation of signal transducer and activator of transcription 3 during focal cerebral ischemia/reperfusion[J]. Neural Regen Res. 2017;12(7):1124-1130.PMID:28852395. [pmid]
6. van Zijl PCM, Brindle K, Lu H, et al. Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo[J]. Curr Opin Chem Biol. 2021;63:209-218. PMID:34298353. [pmid]
7. White P, Ranasinghe S, Chen J, et al. Comparative utility of MRI and EEG for early detection of cortical dysmaturation after postnatal systemic inflammation in the neonatal rat[J]. Brain Behav Immun. 2024;121:104-118.PMID:39043347. [pmid]
8. Su X, Tang W, Luan Z, et al. Protective effect of miconazole on rat myelin sheaths following premature infant cerebral white matter injury[J]. Exp Ther Med. 2018;15(3):2443-2449. PMID:29456649. [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-03-010