562-01-001 ISMRM Abstract

129Xe MRI-based microstructure metrics offer superior sensitivity for COPD identification

Primary: Body - Lung

Secondary: Analysis Methods - Data Processing

562-01-001 · Lung and Thoracic Oncological MRI · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row C

Keywords: Data Processing Chronic obstructive pulmonary disease Magnetic resonance imaging

Accepted

Ziwei Zhang¹, Li Fan ¹, Yuanyuan Cui¹

¹Radiology Department, The Second Affiliated Hospital of Naval Medical University, SHANGHAI, China

Presenting Author: Li Fan

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Global Initiative for Chronic Obstructive Lung Disease (GOLD), “Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2025 Report),” http://goldcopd.org/.

2. Doganay O, Kim M, Gleeson FV. Gas exchange and ventilation imaging of healthy and COPD subjects using hyperpolarized xenon-129 MRI and a 3D alveolar gas-exchange model. Eur Radiol. 2023;33(5):3322-3331. doi:10.1007/s00330-022-09343-9. [doi]

3. Hahn AD, Carey KJ, Barton GP, et al. Hyperpolarized 129Xe MR Spectroscopy in the Lung Shows 1-year Reduced Function in Idiopathic Pulmonary Fibrosis. Radiology. 2022;305(3):688-696. doi:10.1148/radiol.211433. [doi]

4. Kooner HK, McIntosh MJ, Matheson AM, et al. Postacute COVID-19 Syndrome: 129Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later. Radiology. 2023;307(2):e222557. doi:10.1148/radiol.222557. [doi]

5. Klimeš F, Kern AL, Voskrebenzev A, et al. Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. Eur Radiol. 2025;35(2):943-956. doi:10.1007/s00330-024-10893-3. [doi]

6. Kaushik SS, Cleveland ZI, Cofer GP, et al. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med. 2011;65(4):1154-1165. doi:10.1002/mrm.22697. [doi]

7. Ruan W, Zhong J, Wang K, et al. Detection of the mild emphysema by quantification of lung respiratory airways with hyperpolarized xenon diffusion MRI. J Magn Reson Imaging. 2017;45(3):879-888. doi:10.1002/jmri.25408. [doi]

8. Tafti S, Garrison WJ, Mugler JP 3rd, et al. Emphysema Index Based on Hyperpolarized 3He or 129Xe Diffusion MRI: Performance and Comparison with Quantitative CT and Pulmonary Function Tests. Radiology. 2020;297(1):201-210. doi:10.1148/radiol.2020192804. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/562-01-001