Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
531-02-007 / 531-02-007 ISMRM Abstract

The sub-voxel quantitative susceptibility mapping (QSM) reveals iron and pathological protein alterations in early Alzheimer’

Primary: Neuro - Alzheimer's Disease
Secondary: Acquisition & Reconstruction - Quantitative Imaging: head and neck
531-02-007 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
531-02-007 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: Alzheimer's Disease Quantitative Susceptibility Mapping (QSM) Iron quantification Lecanemab Pathological protein
Accepted
Aocai Yang 1, Jiaxiang Xin2, Tao Gong3,4, Guangbin Wang1,3,4
1Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
2MR Research Collaboration, Shanghai, China
3Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250022, China
4Department of Radiograpy, Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
Presenting Author: Aocai Yang

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References

1. Yang A, Du L, Gao W, Liu B, Chen Y, Wang Y, Liu X, Lv K, Zhang W, Xia H, Wu K, Ma G. Associations of cortical iron accumulation with cognition and cerebral atrophy in Alzheimer's disease. Quant Imaging Med Surg. 2022 Sep;12(9):4570-4586. doi: 10.21037/qims-22-7 [doi]
2. Gong NJ, Dibb R, Bulk M, van der Weerd L, Liu C. Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI. Neuroimage. 2019 May 1;191:176-185. doi: 10.1016/j.neuroimage.2019.02.019. [doi]
3. Li Z, Feng R, Liu Q, Feng J, Lao G, Zhang M, Li J, Zhang Y, Wei H. APART-QSM: An improved sub-voxel quantitative susceptibility mapping for susceptibility source separation using an iterative data fitting method. Neuroimage. 2023 Jul 1;274:120148. doi: 10.1016/j.neuroimage.2023.120148. [doi]
4. Zhang Y, Wei H, Cronin MJ, He N, Yan F, Liu C. Longitudinal atlas for normative human brain development and aging over the lifespan using quantitative susceptibility mapping. Neuroimage. 2018 May 1;171:176-189. doi: 10.1016/j.neuroimage.2018.01.008. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-02-007