Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-007 ISMRM Abstract

Distinct Glymphatic Dysfunction Patterns in Glioma and Brain Metastasis Revealed by Diffusion Tensor Imaging–Based ALPS Index

Primary: Neuro - Tumors
Secondary: Neuro - Neurofluids
460-05-007 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Glioma Diffusion MRI Glymphatic system Brain Metastasis DTI-ALPS
Accepted
Jin wang 1, yuxia liang1, Yu Shang2, Qinqin Xie1, Zirui Zhao1, Ming Zhang3, chen niu1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2Xi'an Jiaotong tniversity, China
3Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Presenting Author: Jin wang

Synopsis

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References

1. Yankova G, Bogomyakova O, Tulupov A. The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance. Rev Neurosci. 2021;32(7):693–705
2. Kopeć K, Szleszkowski S, Koziorowski D, et al. Glymphatic system and mitochondrial dysfunction as two crucial players in the pathophysiology of neurodegenerative disorders. Int J Mol Sci. 2023;24(12):10366
3. Yu L, Hu X, Li H, et al. Perivascular spaces, glymphatic system, and MR. Front Neurol. 2022;13:844938
4. Liang W, Sun W, Li C, et al. Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis. Cancer Imaging. 2025;25(1):51
5. Toh CH, Siow TY, Castillo M. Peritumoral brain edema in metastases may be related to glymphatic dysfunction. Front Oncol. 2021;11:725354
6. Hsiao WC, Chang HI, Hsu SW, et al. Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image–along the perivascular space (DTI-ALPS). Neuroscience. 2023;524:11–20

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-05-007