Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-04-006 ISMRM Abstract

DTI revealed microstructure damage in WMH-P was associated with further cognitive decline one year later in CSVD patients

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Neuro - White Matter
663-04-006 · Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Diffusion Tensor Imaging Cognitive impairment Cerebral small vessel disease White matter hyperintensity Penumbra
Accepted
Weisen Wang 1, Yunheng Li2, Xinyuan Zhang3, Jiankun Dai4, 雯佳 彭3, Hao Li2, Xiaoying Bi1
1Department of Neurology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433,China, China
3the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
4MR Research, Beijing, China
Presenting Author: Weisen Wang

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References

1. Maillard P, Fletcher E, Harvey D, et al. White matter hyperintensity penumbra[J]. Stroke. 2011 Jul;42(7):1917-22. DOI: 10.1161/STROKEAHA.110.609768 [doi]
2. Nylander R, Fahlström M, Rostrup E, et al. Quantitative and qualitative MRI evaluation of cerebral small vessel disease in an elderly population: a longitudinal study[J]. Acta Radiol. 2018 May;59(5):612-618. DOI: 10.1177/0284185117725367 [doi]
3. Croall ID, Lohner V, Moynihan B, et al. Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies[J]. Clin Sci (Lond). 2017 Jun 1;131(12):1361-1373. DOI: 10.1042/CS20170146 [doi]
4. Qiu Y, Yu L, Ge X, et al. Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients with Subcortical Vascular Mild Cognitive Impairment[J]. Front Aging Neurosci. 2021; 13:605900. DOI: 10.3389/fnagi.2021.605900 [doi]
5. Promjunyakul NO, Dodge HH, Lahna D, et al. Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time. Neurology. 2018;90(24):e2119-e2126. doi:10.1212/WNL.0000000000005684 [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-04-006