Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-04-004 ISMRM Abstract

Longitudinal assessment of CEST MRI in glioblastoma: The impact of tumor treating fields in addition to temozolomide

Primary: Neuro - Tumors
Secondary: Contrast Mechanisms - CEST / APT / NOE
361-04-004 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B
Keywords: Glioblastoma Temozolomide Amide proton transfer-weighted imaging Tumor treating fields Chemical Exchange Saturation Transfer (CEST) MRI
Accepted
Tim Salomonsson 1, Antonio Giuri2, Malte Knutsson1, Anina Seidemo1, Faris Durmo1, Anna Rydelius3, Xavier S Sarda4, Patrick Liebig5, Stefano Casagranda6, Sara Kinhult7, Mattias Belting7, Johan Bengzon8, Linda Knutsson9,10,11, Pia Maly Sundgren1,12,13
1Diagnostic Radiology, Lund University, Lund, Sweden
2Neuroradiology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
3Department of Neurology, Lund University Hospital, Lund, Sweden
4Department of Pathology, Lund University Hospital, Lund, Sweden
5Siemens Healthineers AG, Erlangen, Germany
6Olea Medical, La Ciotat, France
7Department of Oncology, Lund University Hospital, Lund, Sweden
8Department of Neurosurgery, Lund University Hospital, Lund, Sweden
9F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, United States of America
10Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
11Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
12Department of Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden
13Lund University Bioimaging Centre, Lund University, Lund, Sweden
Presenting Author: Tim Salomonsson

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References

1. Stupp R, Taillibert S, Kanner A, et al. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA. 2017;318(23):2306–2316. doi:10.1001/jama.2017.18718 [doi]
2. Terreno E, Stancanello J, Longo D, et al. Methods for an improved detection of the MRI-CEST effect. Contrast Media Mol. Imaging. 2009;4(5):237–247. doi:10.1002/cmmi.290 [doi]
3. Schüre J-R, Casagranda S, Sedykh M, et al. Fluid suppression in amide proton transfer-weighted (APTw) CEST imaging: New theoretical insights and clinical benefits. Magn. Reson. Med. 2024;91(4):1354–1367. doi:10.1002/mrm.29915 [doi]
4. Moser JC, Salvador E, Deniz K, et al. The mechanisms of action of tumor treating fields. Cancer Res. 2022;82(20):3650–3658. doi:10.1158/0008-5472.CAN-22-0887 [doi]
5. Iv M, Naya L, Sanan S, et al. Tumor treating fields increases blood-brain barrier permeability and relative cerebral blood volume in patients with glioblastoma. Neuroradiol. J. 2024;37(1):107–118. doi:10.1177/19714009231207083 [doi]
6. Onishi R, Sawaya R, Tsuji K, et al. Evaluation of temozolomide treatment for glioblastoma using amide proton transfer imaging and diffusion MRI. Cancers (Basel). 2022;14(8). doi:10.3390/cancers14081907 [doi]
7. Sagiyama K, Mashimo T, Togao O, et al. In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci USA. 2014;111(12):4542–4547. doi:10.1073/pnas.1323855111 [doi]
8. Glas M, Ballo MT, Bomzon Z, et al. The impact of tumor treating fields on glioblastoma progression patterns. Int. J. Radiat. Oncol. Biol. Phys. 2022;112(5):1269–1278. doi:10.1016/j.ijrobp.2021.12.152 [doi]
9. Zhou J, Zaiss M, Knutsson L, et al. Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magn. Reson. Med. 2022;88(2):546–574. doi:10.1002/mrm.29241 [doi]

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http://echo.ismrm.org/p/ISMRM2026/361-04-004