531-01-012 / 531-01-012 ISMRM Abstract

Simultaneous Abdominal PDFF and T2-water Mapping at 0.55T using Free-breathing RADGRASE

Primary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis

Secondary: Body - Liver

531-01-012 · Quantitative Imaging: Applications · Wednesday, 13 May, 8:20 AM–9:56 AM · Roof Terrace

Keywords: Liver Low-Field MRI Quantitative MRI Proton density fat fraction (PDFF) T2 mapping

Accepted

Brian P Toner ¹, Fei Han², Kevin Johnson³, Ute Goerke⁴, Shu-Fu Shih⁵, Eze Ahanonu⁶, Timoteo I Delgado⁵, Hina Arif Tiwari³, Ryan Akhbari⁷, Geoffrey Block⁷, Holden H Wu^5,8, Vibhas Deshpande⁹, Ali Bilgin^1,3,6,10, Maria Altbach^3,10

¹Applied Mathematics, University of Arizona, Tucson, United States of America

²Siemens Medical Solutions, Los Angeles, United States of America

³Radiology and Imaging Science, University of Arizona, Tucson, United States of America

⁴Siemens Medical Solutions, Tucson, United States of America

⁵Radiological Sciences, University of California Los Angeles, Los Angeles, United States of America

⁶Electrical and Computer Engineering, University of Arizona, Tucson, United States of America

⁷Boyer Liver Institute, University of Arizona, Tucson, United States of America

⁸Bioengineering, University of California Los Angeles, Los Angeles, United States of America

⁹Siemens Medical Solutions, Austin, United States of America

¹⁰Biomedical Engineering, University of Arizona, Tucson, United States of America

Presenting Author: Brian P Toner

Synopsis

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References

1. Gmitro A, Kono M, Theilmann R, et al. Radial GRASE: Implementation and applications. Magnetic Resonance in Medicine. 2005;53:1363-1371.

2. Toner B, Han F, Arberet S, et al. Respiratory triggered abdominal T2-weighted imaging for concurrent T2water mapping and PDFF quantification using RADGRASE.” Proceedings of the 2025 Annual Meeting of the ISMRM. Honolulu, HI. 2025.

3. Altbach MI, Graff C, Huang C, et al. Non-invasive imaging of diffuse liver disease using water T2 and fat fractions obtained from breath hold radial GRASE method. Proceedings of the 2010 Annual Meeting of the ISMRM. 2010.

4. Idilman IS, Celik A, Savas B, et al. The feasibility of T2 mapping in the assessment of hepatic steatosis, inflammation, and fibrosis in patients with non-alcoholic fatty liver disease: a preliminary study. Clinical Radiology. 2021;76(9):709.

5. Lebel M, Wilman A. Transverse relaxometry with stimulated echo compensation. Magnetic Resonance in Medicine. 2010;64(4):1005-1014.

6. Zhong X, Nickel MD, Kannengiesser SAR, et al. Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging. Magnetic Resonance in Medicine. 2014;72:1353-1365.

7. Hernando D, Kellman P, Haldar J, et al. Robust water/fat separation in the presence of large field inhomogeneities using a graph cut algorithm. Magnetic Resonance in Medicine. 2010;63:79-90.

8. Fessler JA and Sutton BP. Nonuniform fast Fourier transforms using min-max interpolation. IEEE Transactions on Signal Processing. 2003;51(2):560-574.

9. Toner B, Arberet S, Zhang S, et al. Accelerated free-breathing abdominal T2 mapping with deep learning reconstruction of radial turbo spin-echo data. Magnetic Resonance in Medicine. 2025;94(6):2475-2491.

10. Altbach MI, Bilgin A, Li Z, et al. Processing of radial fast spin-echo data for obtaining T2 estimates from a single k-space data set. Magnetic Resonance in Medicine. 2005; 54:549-559.

11. Huang C, Graff CG, Clarkson EW, et al. T2 mapping from highly undersampled data by reconstruction of principal component coefficient maps using compressed sensing. Magnetic Resonance in Medicine. 2012;67:1355-1366.

12. Huang C, Altbach M, Fakhri G. Pattern recognition for rapid T2 mapping with stimulated echo compensation in MRI: Rationale and an iterative solution. Magnetic Resonance Imaging. 2014;32:969-974.

13. Hamilton G, Yokoo T, Bydder M, et al. In vivo characterization of the liver fat 1H MR spectrum. NMR in Biomedicine. 2011;24(7):784-790).

14. Ren J, Dimitrov AD, Sherry AD, et al. Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. Journal of Lipid Research. 2008;49(9):2055-2062.

15. Del Grande F, Santini F, Herzka DA, et al. Fat-suppression techniques for 3T MR imaging of the musculoskeletal system. RadioGraphics. 2014;34(1):217-233.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-01-012