Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-02-012 ISMRM Abstract

Effect of Age and Sex on DTI-ALPS in Healthy Adults

Primary: Neuro - Aging
Secondary: Diffusion - Diffusion Analysis & Visualization
663-02-012 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D
Keywords: Aging Sex DTI-ALPS Glymphatic Function
Accepted
Julia Chu1,2,3, Rachel J Sharkey1,3, Cheryl R McCreary1,3, feryal E SAAD1, Eric E Smith1,4, Richard Frayne 1,3
1Radiology and Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
2O'Brien Centre for the Health Sciences, University of Calgary, Calgary, Canada
3Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Canada
4Community Health Sciences, University of Calgary, Calgary, Canada
Presenting Author: Richard Frayne

Synopsis

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References

1. Taoka T, et al. Evaluation of glymphatic system activity with the diffusion MR technique: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's dis-ease cases. Jap J Radiology. 2017; 35: 172. doi: 10.1007/s11604-017-0617-z [doi]
2. Ringstad G. Glymphatic imaging: A critical look at the DTI-ALPS index. Neuroradiology. 2024; 66: 157. doi: 10.1007/s00234-023-03270-2 [doi]
3. Taoka T, et al. Diffusion-weighted image analysis along the perivascular space (DWI-ALPS) for evaluating interstitial fluid status: Age dependence in normal subjects. Jap J Radiology. 2022; 40: 894. doi: 10.1007/s11604-022-01275-0 [doi]
4. Dai Z, et al. The aging of glymphatic system in human brain and its correlation with brain charts and neuropsychological functioning. Cerebral Cortex (New York). 2023; 33: 7896. doi: 10.1093/cercor/bhad086 [doi]
5. Hsiao WC, et al. Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS). Neuroscience. 2023; 524: 11–20. doi: 10.1016/j.neuroscience.2023.04.004 [doi]
6. Zhang Y, et al. The influence of demographics and vascular risk factors on glymphatic function measured by diffusion along perivascular space. Front Aging Neurosci. 2021; 13: 693787. doi: 10.3389/fnagi.2021.693787 [doi]
7. Liu X, et al. Cross-vendor test-retest validation of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating glymphatic system function. Aging Dis. 2024; 15: 1885. doi: 10.14336/AD.2023.0321-2 [doi]
8. McCreary CR, et al. Calgary normative study: Design of a prospective longitudinal study to characterise potential quantitative MR biomarkers of neurodegeneration over the adult lifespan. BMJ Open. 2020; 10: e038120. doi: 10.1136/bmjopen-2020-038120 [doi]
9. Chu J, Sharkey RJ, McCreary CR, Saad F, Smith EE, Frayne R. Does covert cerebral small vessel disease modulate early change in glymphatic flow from DTI-ALPS? Presented at: 21st International Symposium on Medical Information Processing and Analysis (SIPAIM); 2025; Pasto, Colombia. doi: pending.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-02-012