663-02-013 ISMRM Abstract

Evaluation of leg muscle fasciculations in in healthy volunteers using diffusion tensor imaging (DTI)

Primary: Musculoskeletal - Muscle

Secondary: Musculoskeletal - Other Musculoskeletal

663-02-013 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D

Keywords: Healthy Volunteers Skeletal Muscle Amyotrophic lateral sclerosis Diffusion Tensor Imaging (DTI) Fasciculation

Accepted

Karleen Oonk^1,2, Linda Heskamp ², Boudewijn Sleutjes¹, Stephan Goedee¹, Leonard van den Berg¹, Martijn Froeling²

¹Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands

²Precision Imaging Group, Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Presenting Author: Linda Heskamp

Synopsis

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References

1. Shefner JM, Al-Chalabi A, Baker MR, Cui LY, de Carvalho M, Eisen A, e.a. A proposal for new diagnostic criteria for ALS. Clin Neurophysiol. 1 augustus 2020;131(8):1975-8.

2. Heskamp L, Schlaffke L, Forsting J, Sleutjes BTHM, Goedee HS, Froeling M. Fasciculation distribution in a healthy population assessed with diffusion tensor imaging. Physiol Rep. maart 2025;13(6):e70247.

3. Fermont J, Arts IMP, Overeem S, Kleine BU, Schelhaas HJ, Zwarts MJ. Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise. Amyotroph Lateral Scler. januari 2010;11(1-2):181-6.

4. Czell D, Goldman B, Weber M. Distribution Of fasciculations in healthy adults after exercise: An ultrasound study. Muscle Nerve. 2016;54(1):132-5.

5. Veraart J, Novikov DS, Christiaens D, Ades-Aron B, Sijbers J, Fieremans E. Denoising of diffusion MRI using random matrix theory. Neuroimage. 15 november 2016;142:394-406.

6. Klein S, Staring M, Murphy K, Viergever MA, Pluim JPW. elastix: a toolbox for intensity-based medical image registration. IEEE Trans Med Imaging. januari 2010;29(1):196-205.

7. Froeling M. QMRTools: a mathematica toolbox for quantitative MRI analysis. J Open Source Softw. 11 juni 2019;4(38):1204.

8. Heskamp L, Birkbeck MG, Hall J, Schofield IanS, Bashford J, Williams TL, e.a. Whole-body fasciculation detection in amyotrophic lateral sclerosis using motor unit MRI. Clin Neurophysiol. 1 mei 2024;161:246-55.

9. Steidle G, Schick F. Addressing spontaneous signal voids in repetitive single-shot DWI of musculature: spatial and temporal patterns in the calves of healthy volunteers and consideration of unintended muscle activities as underlying mechanism. NMR Biomed. 2015;28(7):801-10.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-02-013