504-04-009 ISMRM Abstract

Hyperpolarized metabolic 13C MR spectroscopy and imaging for differentiation of tumor xenografts in fertilized chicken eggs

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

504-04-009 · Cancer Imaging and Spectroscopy · Wednesday, 13 May, 4:00 PM–5:50 PM · Ballroom East

Keywords: In OVO model HET CAM assay Patient-derived tumor organoid Hyperpolarized 13C metabolic MRI Pyruvate-to-lactate conversion

Accepted

Miriam Kirst ¹, Raphela A Ranjan², Rubén Hernández-Vega¹, Sandra Sühnel¹, Nadine Setzer¹, Tobias Haase b. Lobmeyer^3,4, Luca Nagel¹, Geoffrey J Topping¹, Robert Zürl⁵, Alexander Weisser⁵, Florian Odoj⁵, Volker Rasche^3,4, Maximilian Reichert², Franz Schilling^1,6,7

¹Department of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

²Clinic and Polyclinic for Internal Medicine II, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

³Internal Medicine II, Ulm University, Medical Center, Ulm, Germany

⁴Core Facility for Small Animal Imaging, Medical Faculty, Ulm University, Ulm, Germany

⁵RAPID Biomedical GmbH, Rimpar, Germany

⁶Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany

⁷German Cancer Consortium (DKTK) partner site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

Presenting Author: Miriam Kirst

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. DeBord, L. C. et al. The chick chorioallantoic membrane (CAM) as a versatile patient-derived xenograft (PDX) platform for precision medicine and preclinical research. American Journal of Cancer Research 8, 1642 (2018). PMID: 30210932 [pmid]

2. Dantes, Z. et al. Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology. Jci Insight 5 (2020). https://doi.org/10.1172/jci.insight.137809 [doi]

3. Ardenkjær-Larsen, J. H. et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proceedings of the National Academy of Sciences 100, 10158-10163 (2003). https://doi.org/10.1073/pnas.1733835100 [doi]

4. Daniels, C. J. et al. A comparison of quantitative methods for clinical imaging with hyperpolarized 13C‐pyruvate. NMR in Biomedicine 29, 387-399 (2016). https://doi.org/10.1002/nbm.3468 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/504-04-009