Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-02-008 ISMRM Abstract

Insulin signaling and aquaporin 4 interactions regulate cerebrospinal fluid dynamics in the optic nerve

Primary: Neuro - Neurofluids
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
406-02-008 · The Dynamic Brain: Flow, Pressure, and Exchange · Tuesday, 12 May, 1:40 PM–3:30 PM · Auditorium 2
Keywords: Neurodegeneration Glymphatic system Cerebrospinal fluid Insulin resistance Optic Nerve
Accepted
Muneeb A Faiq 1,2,3,4, Thajunnisa A Sajitha1,2,4, Carlos Parra4, Anoop Sainulabdeen4, Choong H Lee3, Jiangyang Zhang5, Gadi Wollstein6,7, Joel S Schuman6,7,8, Kevin C Chan1
1Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford Medicine, Stanford, United States of America
2Tech4Health Institute, New York University Grossman School of Medicine, New York, United States of America
3Department of Radiology, New York University Grossman School of Medicine, New York, United States of America
4Department of Ophthalmology, New York University Grossman School of Medicine, New York, United States of America
5Center for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, United States of America
6Glaucoma Service and Vickie and Jack Farber Vision Research Center, Wills Eye Hospital, Philadelphia, United States of America
7Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, United States of America
8School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, United States of America
Presenting Author: Muneeb A Faiq

Synopsis

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References

1. Tong XJ, Akdemir G, Wadhwa M, Verkman AS, Smith AJ. Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice. Fluids Barriers CNS. 2024 Jan 4;21:1. [PMID: 38178155, DOI: 10.1186/s12987-023-00506-4] [doi] [pmid]
2. Dong Y, Fu Y, Qian X, Lin L, Yuan Y, Li Y, Shao W, Gao Q. Optic nerve head astrocytes contribute to vascular associated effects. Front Med (Lausanne). 2022 Jul 26;9:943986. [PMID: 35957853, DOI: 10.3389/fmed.2022.943986] [doi] [pmid]
3. Faiq MA, Dada R, Kumar A, Saluja D, Dada T. Brain: The Potential Diagnostic and Therapeutic Target for Glaucoma. CNS Neurol Disord Drug Targets. 2016;15(7):839-44. [PMID: 26996164, DOI: 10.2174/1871527315666160321111522] [doi] [pmid]
4. Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, et al., Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018 Dec 18:7:e40070. [PMID: 30561329, DOI: 10.7554/eLife.40070] [doi] [pmid]
5. Agostinone J, Alarcon-Martinez L, Gamlin C, Yu W, Wong ROL, Di Polo A. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain. 2018 Jun 21;141(7):1963–1980. [PMID: 29931057, DOI: 10.1093/brain/awy142] [doi] [pmid]
6. Pieńczykowska K, Bryl A, Mrugacz M. Link Between Metabolic Syndrome, Inflammation, and Eye Diseases. Int J Mol Sci. 2025 Feb 28;26(5):2174. [PMID: 40076793, DOI: 10.3390/ijms26052174] [doi] [pmid]
7. Faiq MA, Sengupta T, Nath M, Velpandian T, Saluja D, Dada D, Dada T, Chan KC. Ocular manifestations of central insulin resistance. Neural Regen Res. 2022 Oct 10;18(5):1139–1146. [PMID: 36255004, DOI: 10.4103/1673-5374.355765] [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/406-02-008