Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
451-02-005 / 451-02-005 ISMRM Abstract

High-resolution 7T QSM reveals laminar and subcortical susceptibility alterations in paediatric focal epilepsy

Primary: Neuro - Epilepsy
Secondary: Pediatrics - Neuro
451-02-005 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
451-02-005 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: Epilepsy Quantitative Susceptibility Mapping (QSM) Paediatric epilepsy 7T MRI
Accepted
Chiara Casella 1,2,3, Katy Vecchiato1,2, Ayse Sila Dokumaci2,4, Philippa Bridgen2,4,5, Pierluigi Di Cio2,4,5, Shaihan Malik2,4, Jo V Hajnal2,4, Sharon L Giles4,5, Jan Sedlaik2,6, Karin Shmueli7, David Carmichael2,4, Jonathan O'Muircheartaigh1,2,3,8
1Research Dept of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
2London Collaborative Ultra high field System (LoCUS), London, United Kingdom
3Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
4Research Dept of Imaging, Physics & Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
5Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
6Institute of Clinical Sciences, Imperial College London, London, United Kingdom
7Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom
8MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Presenting Author: Chiara Casella

Synopsis

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References

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3. Lorio, S. et al. MRI profiling of focal cortical dysplasia using multi-compartment diffusion models. Epilepsia 61, 433–444 (2020).
4. Dokumacı, A. S. et al. Simultaneous Optimization of MP2RAGE T1‐weighted (UNI) and FLuid And White matter Suppression (FLAWS) brain images at 7T using Extended Phase Graph (EPG) Simulations. Magnetic Resonance in Medicine 89, 937–950 (2023).
5. Karsa, A., Punwani, S. & Shmueli, K. An optimized and highly repeatable MRI acquisition and processing pipeline for quantitative susceptibility mapping in the head‐and‐neck region. Magnetic Resonance in Medicine 84, 3206–3222 (2020).
6. Liu, T. et al. Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magnetic resonance in medicine 69, 467–476 (2013).
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9. Bilgic, B., Pfefferbaum, A., Rohlfing, T., Sullivan, E. V. & Adalsteinsson, E. MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping. Neuroimage 59, 2625–2635 (2012).
10. Belsley, D. A., Kuh, E. & Welsch, R. E. Regression Diagnostics: Identifying Influential Data and Sources of Collinearity. (John Wiley & Sons, 2005).
11. Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M. & Nichols, T. E. Permutation inference for the general linear model. NeuroImage 92, 381–397 (2014).
12. Kiersnowski, O. C. et al. Quantitative susceptibility mapping identifies hippocampal and other subcortical grey matter tissue composition changes in temporal lobe epilepsy. Hum Brain Mapp 44, 5047–5064 (2023).
13. Hect, J. L., Daugherty, A. M., Hermez, K. M. & Thomason, M. E. Developmental variation in regional brain iron and its relation to cognitive functions in childhood. Dev Cogn Neurosci 34, 18–26 (2018).
14. Larsen, B. et al. Longitudinal Development of Brain Iron Is Linked to Cognition in Youth. J. Neurosci. 40, 1810–1818 (2020).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/451-02-005