Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-02-001 ISMRM Abstract

Comparison of myelin-sensitive quantitative MR and histological markers in Alzheimer's disease tissue samples

Accepted
Amaya Murguia1, Andrea M Jacobson2, Scott D Swanson3,4, Ulrich Scheven5, Jon-Fredrik Nielsen 1,2,3, Jeffrey A Fessler1,2,3, Navid Seraji-Bozorgzad6
1Department of Electrical and Computer Engineering, University of Michigan, Ann Arbor, United States of America
2Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States of America
3Department of Radiology, University of Michigan, Ann Arbor, United States of America
4Department of Biophysics, University of Michigan, Ann Arbor, United States of America
5Department of Mechanical Engineering, University of Michigan, Ann Arbor, United States of America
6Department of Neurology, University of Michigan, Ann Arbor, United States of America
Presenting Author: Jon-Fredrik Nielsen

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Papuć, E., & Rejdak, K. (2018). The role of myelin damage in Alzheimer’s disease pathology. Archives of Medical Science, 16(2), 345-341. https://doi.org/10.5114/aoms.2018.76863 [doi]
2. Dao, E., Tam, R., Hsiung, G. Y. R., Ten Brinke, L., Crockett, R., Barha, C. K., ... & Liu-Ambrose, T. (2021). Exploring the contribution of myelin content in normal appearing white matter to cognitive outcomes in cerebral small vessel disease. Journal of Alzheimer’s Disease, 80(1), 91-101. https://doi.org/10.3233/JAD-201134 [doi]
3. McAleese, K. E., Miah, M., Graham, S., Hadfield, G. M., Walker, L., Johnson, M., ... & Attems, J. (2021). Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology. Acta neuropathologica, 142(6), 937-950. https://doi.org/10.1007/s00401-021-02376-2 [doi]
4. Laule, C., Kozlowski, P., Leung, E., Li, D. K., MacKay, A. L., & Moore, G. W. (2008). Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology. Neuroimage, 40(4), 1575-1580. https://doi.org/10.1016/j.neuroimage.2007.12.008 [doi]
5. Whittall, K. P., & MacKay, A. L. (1989). Quantitative interpretation of NMR relaxation data. Journal of Magnetic Resonance (1969), 84(1), 134-152. https://doi.org/10.1016/0022-2364(89)90011-5 [doi]
6. Sled, J. G., & Pike, G. B. (2001). Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 46(5), 923-931. https://doi.org/10.1002/mrm.1278 [doi]
7. Henkelman, R. M., Huang, X., Xiang, Q. S., Stanisz, G. J., Swanson, S. D., & Bronskill, M. J. (1993). Quantitative interpretation of magnetization transfer. Magnetic resonance in medicine, 29(6), 759-766. https://doi.org/10.1002/mrm.1910290607 [doi]
8. Murguia, A., Swanson, S. D., Scheven, U., Jacobson, A., Nielsen, J. F., Fessler, J. A., & Seraji‐Bozorgzad, N. (2025). Impact of tissue sample preparation methods on myelin‐sensitive quantitative MR imaging. Magnetic Resonance in Medicine, 94(5), 2071-2085. https://doi.org/10.1002/mrm.30623 [doi]
9. Stanisz, G. J., Odrobina, E. E., Pun, J., Escaravage, M., Graham, S. J., Bronskill, M. J., & Henkelman, R. M. (2005). T1, T2 relaxation and magnetization transfer in tissue at 3T. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 54(3), 507-512. https://doi.org/10.1002/mrm.20605 [doi]
10. Mohammadi, S., & Callaghan, M. F. (2021). Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging. Journal of neuroscience methods, 348, 108990. https://doi.org/10.1016/j.jneumeth.2020.108990 [doi]
11. Berman, S., West, K. L., Does, M. D., Yeatman, J. D., & Mezer, A. A. (2018). Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex. Neuroimage, 182, 304-313. https://doi.org/10.1016/j.neuroimage.2017.06.076 [doi]
12. Dortch, R. D., Harkins, K. D., Juttukonda, M. R., Gore, J. C., & Does, M. D. (2013). Characterizing inter‐compartmental water exchange in myelinated tissue using relaxation exchange spectroscopy. Magnetic resonance in medicine, 70(5), 1450-1459. https://doi.org/10.1002/mrm.24571 [doi]
13. Dula, A. N., Gochberg, D. F., Valentine, H. L., Valentine, W. M., & Does, M. D. (2010). Multiexponential T2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 63(4), 902-909. https://doi.org/10.1002/mrm.22267 [doi]
14. Harkins, K. D., Dula, A. N., & Does, M. D. (2012). Effect of intercompartmental water exchange on the apparent myelin water fraction in multiexponential T2 measurements of rat spinal cord. Magnetic resonance in medicine, 67(3), 793-800. https://doi.org/10.1002/mrm.23053 [doi]
15. Dyakin, V. V., Chen, Y., Branch, C. A., Yuan, A., Rao, M., Kumar, A., ... & Nixon, R. A. (2010). The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models. Neuroimage, 51(3), 1098-1105. https://doi.org/10.1016/j.neuroimage.2010.03.013 [doi]
16. Petzold, A., Tozer, D. J., & Schmierer, K. (2011). Axonal damage in the making: neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter. Experimental neurology, 232(2), 234-239. https://doi.org/10.1016/j.expneurol.2011.09.011 [doi]
17. Duhamel, G., Prevost, V. H., Cayre, M., Hertanu, A., Mchinda, S., Carvalho, V. N., ... & Girard, O. M. (2019). Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy. Neuroimage, 199, 289-303. https://doi.org/10.1016/j.neuroimage.2019.05.061 [doi]

Cite this abstract