Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-002 / 352-03-002 ISMRM Abstract

The Night Shift: Mapping Brain Fluctuations in Sleep with High Performance MRI

Primary: Neuro - Neurofluids
Secondary: Diffusion - Diffusion Reconstruction
352-03-002 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-002 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Neurofluids Functional magnetic resonance imaging Sleep disorders Glymphatic system (GS) High Performance Gradients
Accepted
Nastaren Abad1, Isabelle Heukensfeldt Jansen1, Chitresh Bhushan1, Muhan Shao1, Afis Ajala1, Ana Beatriz Solana 2, Florian Wiesinger2, Brice Fernandez3, Suchandrima Banerjee4, Angeliki Pollatou5, J. Kevin DeMarco6, Gail H Kohls5, Herman D Morris5, Vincent B Ho5,6, Myeongjin Jeong7, Melanie Boly7, Rasmus Birn7, Maria Greufe7, Steven R Kecskemeti7, Barbara B Bendlin7, ANDREW Alexander7, J. Kent Werner5,6, Luca Marinelli1
1GE HealthCare Technology and Innovation Center, Niskayuna, United States of America
2GE Healthcare, Munich, Germany
3GE HealthCare, Buc, France
4GE HealthCare Global MR Applications & Workflow, Menlo Park, United States of America
5Uniformed Services University of the Health Sciences, Bethesda, United States of America
6Walter Reed National Military Medical Center, Bethesda, United States of America
7University of Wisconsin - Madison, Madison, United States of America
Presenting Author: Ana Beatriz Solana

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Klinzing, J.G., N. Niethard, and J. Born, Mechanisms of systems memory consolidation during sleep. Nat Neurosci, 2019. 22(10): p. 1598-1610.
2. Brodt, S., et al., Sleep-A brain-state serving systems memory consolidation. Neuron, 2023. 111(7): p. 1050-1075.
3. Buongiorno, M., et al., Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases. BMC Neurol, 2023. 23(1): p. 417.
4. Christensen, J., et al., Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties. Prog Neurobiol, 2021. 198: p. 101917.
5. Keir, L.H.M. and D.P. Breen, New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson's disease. J Neurol, 2020. 267(1): p. 288-294.
6. Lohela, T.J., T.O. Lilius, and M. Nedergaard, The glymphatic system: implications for drugs for central nervous system diseases. Nat Rev Drug Discov, 2022. 21(10): p. 763-779.
7. Iliff, J.J., et al., A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med, 2012. 4(147): p. 147ra111.
8. Hauglund, N.L., et al., Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep. Cell, 2025. 188(3): p. 606-622 e17.
9. Bohr, T., et al., The glymphatic system: Current understanding and modeling. iScience, 2022. 25(9): p. 104987.
10. Richmond, S.B., et al., Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain-wide glymphatic function. Eur J Neurosci, 2023. 57(10): p. 1689-1704.
11. Song, C., et al., fMRI spectral signatures of sleep. Proc Natl Acad Sci U S A, 2022. 119(30): p. e2016732119.
12. Horovitz, S.G., et al., Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Hum Brain Mapp, 2008. 29(6): p. 671-82.
13. Fukunaga, M., et al., Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages. Magn Reson Imaging, 2006. 24(8): p. 979-92.
14. Davis, B., et al., Progression to deep sleep is characterized by changes to BOLD dynamics in sensory cortices. Neuroimage, 2016. 130: p. 293-305.
15. Wiesinger, F., A. Menini, and A.B. Solana, Looping Star. Magn Reson Med, 2019. 81(1): p. 57-68.
16. Wiesinger, F. and A.B. Solana, Looping Star: Time-Multiplexed, Gradient Echo Zero TE MR Imaging, in MRI of Short- and Ultrashort-T2 Tissues: Making the Invisible Visible, J. Du and G.M. Bydder, Editors. 2023, Springer International Publishing: Cham. p. 119-131.
17. Dionisio-Parra, B., et al., Looping Star fMRI in Cognitive Tasks and Resting State. J Magn Reson Imaging, 2020. 52(3): p. 739-751.
18. Abad, N. Sleeping Under the Looping Star: Identifying BOLD Spectral Correlates of Sleep with Silent fMRI. in International Society for Magnetic Resonance in Medicine. 2025. Honolulu, HI.
19. Jansen, I.H. Optimization of Simultaneous Coherent/Incoherent Motion Imaging (SCIMI): Combined Diffusion and Velocimetry for Glymphatic Circulation. in Proc Intl Soc Magn Reson Med. 2024.
20. Abad, N., et al. Silent resting-state fMRI using Looping Star Multi-echo acquisition in a 3T high-performance gradient (300 mT/m & 750 T/m/s) MRI system (MAGNUS). in International Society for Magnetic Resonance in Medicine. 2024. Singapore.
21. Pruessmann, K.P., et al., Advances in sensitivity encoding with arbitrary k-space trajectories. Magn Reson Med, 2001. 46(4): p. 638-51.
22. Madhavan, R., et al., Longitudinal Resting State Functional Connectivity Predicts Clinical Outcome in Mild Traumatic Brain Injury. J Neurotrauma, 2019. 36(5): p. 650-660.
23. Kundu, P., et al., Differentiating BOLD and non-BOLD signals in fMRI time series using multi-echo EPI. Neuroimage, 2012. 60(3): p. 1759-70.
24. Rolls, E.T., et al., Automated anatomical labelling atlas 3. Neuroimage, 2020. 206: p. 116189.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-002