Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-04-010 ISMRM Abstract

Quantitative and multivariate discrimination of healthy and tumor metabolite profiles acquired with in vivo MR spectroscopy

Primary: Neuro - Tumors
Secondary: Contrast Mechanisms - Spectroscopy
362-04-010 · Spectroscopy and Spectroscopic Imaging: Neuro I · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row C
Keywords: Tumors Glioma MR Spectroscopy (MRS) High field MRI Multivariate Statistical Analysis
Accepted
Rachel M Goldberg 1,2, Candace C Fleischer2,3
1Laney Graduate School, Emory University, Atlanta, United States of America
2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, United States of America
3Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, United States of America
Presenting Author: Rachel M Goldberg

Synopsis

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References

1. Bornstein, R., et al., Glutamine metabolism in diseases associated with mitochondrial dysfunction. Mol Cell Neurosci, 2023. 126: p. 103887.
2. Wise, D.R. and C.B. Thompson, Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci, 2010. 35(8): p. 427-33.
3. Márquez, J., et al., Glutamine Addiction In Gliomas. Neurochemical Research, 2017. 42(6): p. 1735-1746.
4. Ekici, S., et al., Characterization of dysregulated glutamine metabolism in human glioma tissue with 1H NMR. Scientific reports, 2020. 10(1): p. 20435.
5. Ramadan, S., A. Lin, and P. Stanwell, Glutamate and glutamine: a review of in vivo MRS in the human brain. NMR Biomed, 2013. 26(12): p. 1630-46.
6. McCarthy, L., et al., Application of 7T MRS to high-grade gliomas. American Journal of Neuroradiology, 2022. 43(10): p. 1378-1395.
7. Shaffer, A., et al., Ultra-high-field MRI in the diagnosis and management of gliomas: a systematic review. Frontiers in neurology, 2022. 13: p. 857825.
8. Subramani, E., et al., Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment. Cancer Res, 2020. 80(22): p. 5098-5108.
9. Taxt, T. and A. Lundervold, Multispectral analysis of the brain using magnetic resonance imaging. IEEE Trans Med Imaging, 1994. 13(3): p. 470-81.
10. Guerrero-Gonzalez, J.M., et al., Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI. Neuroimage, 2022. 260: p. 119475.
11. Behrendt, F., et al. Leveraging the Mahalanobis Distance to Enhance Unsupervised Brain MRI Anomaly Detection. 2024. Cham: Springer Nature Switzerland.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-04-010