462-02-009 ISMRM Abstract

Disease-Specific Signatures of Genetic and Neuroimaging Factors Underlying Clinical Heterogeneity in Psychotic Disorders

Primary: Neuro - Psychiatric Disorders

Secondary: Diffusion - Microstructure

462-02-009 · Diffusion MRI Neuroscience · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row C

Keywords: Genetics Schizophrenia Neuroimaging Bipolar disorder Behavior

Accepted

Chengmin Yang ¹, Huilou Liang², Su Lui¹

¹West China Hospital of Sichuan University, Chendu, China

²GE HealthCare MR Research, Beijing, China

Presenting Author: Chengmin Yang

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References

1. Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604(7906):502-8.

2. Weinberger DR, Radulescu E. Finding the Elusive Psychiatric "Lesion" With 21st-Century Neuroanatomy: A Note of Caution. The American journal of psychiatry. 2016;173(1):27-33.

3. Chen NK, Guidon A, Chang HC, Song AW. A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE). NeuroImage. 2013;72:41-7.

4. Thiel K, Flinkenflügel K, Grotegerd D, Jurischka C, Hubbert J, Hahn T, et al. Disease progression in bipolar disorder in relation to white matter microstructure: A comprehensive approach based on staging models. European psychiatry : the journal of the Association of European Psychiatrists. 2025;68(1):e148.

5. Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature genetics. 2019;51(5):793-803.

6. Howes OD, Murray RM. Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet (London, England). 2014;383(9929):1677-87.

7. Murray GK, Lin T, Austin J, McGrath JJ, Hickie IB, Wray NR. Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review. JAMA psychiatry. 2021;78(2):210-9.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/462-02-009