Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
404-03-002 ISMRM Abstract

Increased Blood-Brain Barrier Water Permeability in Neuromyelitis Optica Spectrum Disorder during Remission Period

Primary: Neuro - Multiple Sclerosis
Secondary: Neuro - Neuroinflammation
404-03-002 · Multiscale MRI in Neuroinflammation · Tuesday, 12 May, 1:40 PM–3:30 PM · Ballroom East
Keywords: Multiple Sclerosis Neuromyelitis optica spectrum disorder Brain-blood barrier permeability
Accepted
Shuwan Yu1, Yehe Wang2, Ning Xu1, Zixuan Lin3, Xihai Zhao1, Mangsuo Zhao4
1Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China
2Tsinghua University, Beijing, China
3Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
4Tsinghua Uiversity Yuquan Hospital, Beijing, China
Presenting Author: Haoxiang Li

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References

1. Papadopoulos M C, Verkman A S. Aquaporin 4 and neuromyelitis optica. Lancet Neurol, 2012, 11(6): 535-544. doi: 10.1016/S1474-4422(12)70133-3. [doi]
2. Carnero Contentti E, Correale J. Neuromyelitis optica spectrum disorders: From pathophysiology to therapeutic strategies. J Neuroinflammation, 2021, 18(1): 208. doi: 10.1186/s12974-021-02249-1. [doi]
3. Lin Z, Li Y, Su P, et al. Non-contrast mr imaging of blood-brain barrier permeability to water. Magn Reson Med, 2018, 80(4): 1507-1520. doi: 10.1002/mrm.27141. [doi]
4. Lin Z, Jiang D, Liu D, et al. Noncontrast assessment of blood-brain barrier permeability to water: Shorter acquisition, test-retest reproducibility, and comparison with contrast-based method. Magn Reson Med, 2021, 86(1): 143-156. doi: 10.1002/mrm.28687. [doi]
5. Peng S L, Su P, Wang F N, et al. Optimization of phase-contrast mri for the quantification of whole-brain cerebral blood flow. J Magn Reson Imaging, 2015, 42(4): 1126-1133. doi: 10.1002/jmri.24866. [doi]
6. Mori S, Wu D, Ceritoglu C, et al. Mricloud: Delivering high-throughput mri neuroinformatics as cloud-based software as a service. Computing in Science & Engineering, 2016, 18(5): 21-35. doi: 10.1109/MCSE.2016.93. [doi]
7. Wang H, Pouch A, Takabe M, et al. Multi-atlas segmentation with robust label transfer and label fusion. Inf Process Med Imaging, 2013, 23: 548-559. doi: 10.1007/978-3-642-38868-2_46. [doi]
8. Shimizu F, Nishihara H, Kanda T. Blood-brain barrier dysfunction in immuno-mediated neurological diseases. Immunol Med, 2018, 41(3): 120-128. doi: 10.1080/25785826.2018.1531190. [doi]
9. Chawla S, Ge Y, Wuerfel J, et al. Longitudinal ultra-high field mri of brain lesions in neuromyelitis optica spectrum disorders. Mult Scler Relat Disord, 2020, 42: 102066. doi: 10.1016/j.msard.2020.102066. [doi]

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http://echo.ismrm.org/p/ISMRM2026/404-03-002