502-04-006 / 271-01-006 ISMRM Abstract

Advanced Diffusion-Weighted Imaging Markers for Prediction of Breast Cancer Treatment Response in a Multisite Trial

Primary: Body - Breast

Secondary: Diffusion - Diffusion Modeling

502-04-006 · New Developments in Breast MRI · Wednesday, 13 May, 4:00 PM–5:50 PM · Hall 1B

271-01-006 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters

Keywords: Breast cancer Diffusion-weighted MRI Diffusion kurtosis imaging Neoadjuvant Chemotherapy Restriction Spectrum Imaging

Accepted

Debosmita Biswas ^1,2, Chen Shen³, Dariya Malyarenko⁴, Patrick J Bolan⁵, Stephane Loubrie⁶, Isabella Li¹, Anum Kazerouni¹, Brendon Moloney⁷, Xin Li⁷, Dallas Turley⁸, Marissa Lawson¹, Rebecca Rakow-Penner^6,9,10, Jennifer M Specht¹¹, Suzanne Dintzis¹², Habib Rahbar¹³, Thomas L Chenevert⁴, James H Holmes¹⁴, Wei Huang³, Savannah Partridge¹³

¹Radiology, University of Washington, Seattle, United States of America

²Bioengineering, University of Washington, Seattle, United States of America

³Corewell Health, Detroit, United States of America

⁴University of Michigan, Ann Arbor, United States of America

⁵Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, United States of America

⁶University of California, Berkeley, United States of America

⁷Oregon Health & Science University (OHSU), Portland, United States of America

⁸Philips Healthcare (Bothell), Bothell, United States of America

⁹University of California, San Diego, La Jolla, CA, United States of America, United States of America

¹⁰Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States of America, United States of America

¹¹Division of Medical Oncology, University of Washington, Seattle, United States of America

¹²Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America

¹³University of Washington, Seattle, United States of America

¹⁴University of Iowa, Iowa City, United States of America

Presenting Author: Debosmita Biswas

Synopsis

Motivation:

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References

1. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-247.

2. Partridge SC, Zhang Z, Newitt DC, Gibbs JE, Chenevert TL, Rosen MA, Bolan PJ, Marques HS, Romanoff J, Cimino L, Joe BN, Umphrey HR, Ojeda-Fournier H, Dogan B, Oh K, Abe H, Drukteinis JS, Esserman LJ, Hylton NM; ACRIN 6698 Trial Team and I-SPY 2 Trial Investigators. Diffusion-weighted MRI Findings Predict Pathologic Response in Neoadjuvant Treatment of Breast Cancer: The ACRIN 6698 Multicenter Trial. Radiology. 2018 Dec;289(3):618-627. doi: 10.1148/radiol.2018180273. Epub 2018 Sep 4. PMID: 30179110; PMCID: PMC6283325. [doi] [pmid]

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4. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986 Nov;161(2):401-7. doi: 10.1148/radiology.161.2.3763909. PMID: 3763909. [doi] [pmid]

5. Jensen JH, Helpern JA. MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed. 2010 Aug;23(7):698-710. doi: 10.1002/nbm.1518. PMID: 20632416; PMCID: PMC2997680. [doi] [pmid]

6. Malyarenko DI, Swanson SD, McGarry SD, LaViolette PS, Chenevert TL. The impeded diffusion fraction quantitative imaging assay demonstrated in multi-exponential diffusion phantom and prostate cancer. Magn Reson Med. 2022 Apr;87(4):2053-2062. doi: 10.1002/mrm.29075. Epub 2021 Nov 14. PMID: 34775621; PMCID: PMC8810585. [doi] [pmid]

7. Besser AH, Fang LK, Tong MW, Andreassen MMS, Ojeda-Fournier H, Conlin CC, Loubrie S, Seibert TM, Hahn ME, Kuperman JM, Wallace AM, Dale AM, Rodríguez-Soto AE, Rakow-Penner RA. Tri-Compartmental Restriction Spectrum Imaging Breast Model Distinguishes Malignant Lesions from Benign Lesions and Healthy Tissue on Diffusion-Weighted Imaging. Cancers (Basel). 2022 Jun 30;14(13):3200. doi: 10.3390/cancers14133200. PMID: 35804972; PMCID: PMC9264763. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/502-04-006